Global Whole-Genome Resequencing of Beef Cattle Reveals Characteristic Traits Related Genes in Pinan Cattle
Beef cattle breed improvement holds strategic significance in the livestock industry. Pinan cattle, developed through years of selective breeding in Xinye County, Henan Province, exhibit superior traits including thin skin, fine bone structure, rapid growth, high dressing percentage, excellent meat...
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MDPI AG
2025-05-01
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| Series: | Animals |
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| author | Dongdong Bo Yuanyuan Wang Yilin Bai Jing Li Jiameng Shen Jinxiao Wei Yueyu Bai |
| author_facet | Dongdong Bo Yuanyuan Wang Yilin Bai Jing Li Jiameng Shen Jinxiao Wei Yueyu Bai |
| author_sort | Dongdong Bo |
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| description | Beef cattle breed improvement holds strategic significance in the livestock industry. Pinan cattle, developed through years of selective breeding in Xinye County, Henan Province, exhibit superior traits including thin skin, fine bone structure, rapid growth, high dressing percentage, excellent meat yield, and superior feed efficiency. However, research on the genetic characteristics of Pinan cattle remains in its infancy. In this study, we investigated population genetic diversity and positive selection signals in Pinang cattle based on whole-genome resequencing data. Using a selective sweep approach, we identified 98 candidate genes associated with growth, reproduction, and immunity, along with 13 high-confidence missense mutations, which may underlie key traits in this population. Based on the critical roles of the <i>NDN</i> and <i>PARVA</i> genes in reproduction and muscle development, the predominant T allele at the <i>NDN</i> c.581T > A and <i>PARVA</i> c.893T > A loci in the Pinan cattle population may partially explain their advantages in sexual precocity and rapid growth compared to other breeds or populations. This study provides an important theoretical basis for the genetic improvement of native beef cattle and lays a scientific foundation for further investigation into the growth and development mechanisms of Pinan cattle. |
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| issn | 2076-2615 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Animals |
| spelling | doaj-art-734e8adb1dd5418e8f4e47cdcbd2ae0a2025-08-20T02:23:04ZengMDPI AGAnimals2076-26152025-05-011511162610.3390/ani15111626Global Whole-Genome Resequencing of Beef Cattle Reveals Characteristic Traits Related Genes in Pinan CattleDongdong Bo0Yuanyuan Wang1Yilin Bai2Jing Li3Jiameng Shen4Jinxiao Wei5Yueyu Bai6School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, ChinaSchool of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, ChinaHenan Provincial Center of Seed Industry Development, Zhengzhou 450007, ChinaSchool of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, ChinaBeef cattle breed improvement holds strategic significance in the livestock industry. Pinan cattle, developed through years of selective breeding in Xinye County, Henan Province, exhibit superior traits including thin skin, fine bone structure, rapid growth, high dressing percentage, excellent meat yield, and superior feed efficiency. However, research on the genetic characteristics of Pinan cattle remains in its infancy. In this study, we investigated population genetic diversity and positive selection signals in Pinang cattle based on whole-genome resequencing data. Using a selective sweep approach, we identified 98 candidate genes associated with growth, reproduction, and immunity, along with 13 high-confidence missense mutations, which may underlie key traits in this population. Based on the critical roles of the <i>NDN</i> and <i>PARVA</i> genes in reproduction and muscle development, the predominant T allele at the <i>NDN</i> c.581T > A and <i>PARVA</i> c.893T > A loci in the Pinan cattle population may partially explain their advantages in sexual precocity and rapid growth compared to other breeds or populations. This study provides an important theoretical basis for the genetic improvement of native beef cattle and lays a scientific foundation for further investigation into the growth and development mechanisms of Pinan cattle.https://www.mdpi.com/2076-2615/15/11/1626Pinan cattleselection signaturecandidate genespopulation genetic structure<i>NDN</i> gene<i>PARVA</i> gene |
| spellingShingle | Dongdong Bo Yuanyuan Wang Yilin Bai Jing Li Jiameng Shen Jinxiao Wei Yueyu Bai Global Whole-Genome Resequencing of Beef Cattle Reveals Characteristic Traits Related Genes in Pinan Cattle Animals Pinan cattle selection signature candidate genes population genetic structure <i>NDN</i> gene <i>PARVA</i> gene |
| title | Global Whole-Genome Resequencing of Beef Cattle Reveals Characteristic Traits Related Genes in Pinan Cattle |
| title_full | Global Whole-Genome Resequencing of Beef Cattle Reveals Characteristic Traits Related Genes in Pinan Cattle |
| title_fullStr | Global Whole-Genome Resequencing of Beef Cattle Reveals Characteristic Traits Related Genes in Pinan Cattle |
| title_full_unstemmed | Global Whole-Genome Resequencing of Beef Cattle Reveals Characteristic Traits Related Genes in Pinan Cattle |
| title_short | Global Whole-Genome Resequencing of Beef Cattle Reveals Characteristic Traits Related Genes in Pinan Cattle |
| title_sort | global whole genome resequencing of beef cattle reveals characteristic traits related genes in pinan cattle |
| topic | Pinan cattle selection signature candidate genes population genetic structure <i>NDN</i> gene <i>PARVA</i> gene |
| url | https://www.mdpi.com/2076-2615/15/11/1626 |
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