First experiences with multiple bilateral insertions of a newly developed microcatheter-compatible endovascular electroencephalogram electrode for humans with epilepsy
Identifying epileptogenic zones non-invasively is challenging due to signal interference by the scalp and skull, necessitating invasive methods like subdural recordings and stereoelectroencephalography. Recent microcatheter advancements suggest that a microcatheter-compatible endovascular EEG (eEEG)...
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Elsevier
2025-03-01
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| Series: | Epilepsy & Behavior Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589986425000085 |
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| author | Yosuke Masuda Ayataka Fujimoto Hisayuki Hosoo Kota Araki Hiroki Ishida Mitsuyo Nishimura Aiki Marushima Eiichi Ishikawa Yuji Matsumaru |
| author_facet | Yosuke Masuda Ayataka Fujimoto Hisayuki Hosoo Kota Araki Hiroki Ishida Mitsuyo Nishimura Aiki Marushima Eiichi Ishikawa Yuji Matsumaru |
| author_sort | Yosuke Masuda |
| collection | DOAJ |
| description | Identifying epileptogenic zones non-invasively is challenging due to signal interference by the scalp and skull, necessitating invasive methods like subdural recordings and stereoelectroencephalography. Recent microcatheter advancements suggest that a microcatheter-compatible endovascular EEG (eEEG) device could overcome these barriers. We developed a thin, flexible eEEG electrode, the EP-01, for use with current microcatheters. The EP-01, comprising a platinum electrode and alloy wire coated with an electrically non-conductive polymer, was inserted via the jugular veins under local anesthesia. The EP-01 electrodes were planned to be placed in six locations: bilateral transverse sinuses, bilateral cavernous sinuses, and the anterior and posterior superior sagittal sinuses. We conducted a first-in-human study demonstrating the feasibility and efficacy of the EP-01electrodes in simultaneously recording intracranial EEG signals from multiple brain locations. The EP-01 electrodes were successfully placed as planned, except for one, without complications. Simultaneous eEEG and scalp EEG recordings were performed during a Wada test to evaluate efficacy and safety. The eEEG recorded alpha waves and slow-wave activity during propofol administration, corresponding to scalp EEG findings, with amplitudes 3–4 times higher. Post-procedural assessments confirmed cranial vessels’ patency and absence of complications. The EP-01 successfully recorded EEG signals at multiple locations in the human brain using an endovascular approach. Compared to scalp EEG, the present approach seems to have the potential to record higher-amplitude EEG. However, the study was limited to short-term recordings without epileptic discharges. Further investigations, including long-term placement, are thus needed for seizure recordings and safety evaluations. |
| format | Article |
| id | doaj-art-73410f145c4d4a349b031bd5d742a07d |
| institution | DOAJ |
| issn | 2589-9864 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Epilepsy & Behavior Reports |
| spelling | doaj-art-73410f145c4d4a349b031bd5d742a07d2025-08-20T02:56:51ZengElsevierEpilepsy & Behavior Reports2589-98642025-03-012910074810.1016/j.ebr.2025.100748First experiences with multiple bilateral insertions of a newly developed microcatheter-compatible endovascular electroencephalogram electrode for humans with epilepsyYosuke Masuda0Ayataka Fujimoto1Hisayuki Hosoo2Kota Araki3Hiroki Ishida4Mitsuyo Nishimura5Aiki Marushima6Eiichi Ishikawa7Yuji Matsumaru8Department of Neurosurgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Comprehensive Epilepsy Center, University of Tsukuba Hospital, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8576, Japan; Corresponding author.Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, 2-12-12, Sumiyoshi, Naka-ku, Hamamatsu, Shizuoka 430-8558, JapanDepartment of Stroke, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Neurosurgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Comprehensive Epilepsy Center, University of Tsukuba Hospital, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8576, Japan; Department of Stroke, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8575, JapanEpsilon Medical Inc., 8-6, Kobunacyo, Nihonbashi, Chuo-ku, Tokyo 103-0024, JapanComprehensive Epilepsy Center, University of Tsukuba Hospital, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8576, JapanDepartment of Stroke, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8575, JapanDepartment of Neurosurgery, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Comprehensive Epilepsy Center, University of Tsukuba Hospital, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8576, JapanDepartment of Stroke, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki 305-8575, Japan; Epsilon Medical Inc., 8-6, Kobunacyo, Nihonbashi, Chuo-ku, Tokyo 103-0024, JapanIdentifying epileptogenic zones non-invasively is challenging due to signal interference by the scalp and skull, necessitating invasive methods like subdural recordings and stereoelectroencephalography. Recent microcatheter advancements suggest that a microcatheter-compatible endovascular EEG (eEEG) device could overcome these barriers. We developed a thin, flexible eEEG electrode, the EP-01, for use with current microcatheters. The EP-01, comprising a platinum electrode and alloy wire coated with an electrically non-conductive polymer, was inserted via the jugular veins under local anesthesia. The EP-01 electrodes were planned to be placed in six locations: bilateral transverse sinuses, bilateral cavernous sinuses, and the anterior and posterior superior sagittal sinuses. We conducted a first-in-human study demonstrating the feasibility and efficacy of the EP-01electrodes in simultaneously recording intracranial EEG signals from multiple brain locations. The EP-01 electrodes were successfully placed as planned, except for one, without complications. Simultaneous eEEG and scalp EEG recordings were performed during a Wada test to evaluate efficacy and safety. The eEEG recorded alpha waves and slow-wave activity during propofol administration, corresponding to scalp EEG findings, with amplitudes 3–4 times higher. Post-procedural assessments confirmed cranial vessels’ patency and absence of complications. The EP-01 successfully recorded EEG signals at multiple locations in the human brain using an endovascular approach. Compared to scalp EEG, the present approach seems to have the potential to record higher-amplitude EEG. However, the study was limited to short-term recordings without epileptic discharges. Further investigations, including long-term placement, are thus needed for seizure recordings and safety evaluations.http://www.sciencedirect.com/science/article/pii/S2589986425000085Endovascular electroencephalogram electrodeEpilepsySeizure focusMicrocatheter-compatible electrodes |
| spellingShingle | Yosuke Masuda Ayataka Fujimoto Hisayuki Hosoo Kota Araki Hiroki Ishida Mitsuyo Nishimura Aiki Marushima Eiichi Ishikawa Yuji Matsumaru First experiences with multiple bilateral insertions of a newly developed microcatheter-compatible endovascular electroencephalogram electrode for humans with epilepsy Epilepsy & Behavior Reports Endovascular electroencephalogram electrode Epilepsy Seizure focus Microcatheter-compatible electrodes |
| title | First experiences with multiple bilateral insertions of a newly developed microcatheter-compatible endovascular electroencephalogram electrode for humans with epilepsy |
| title_full | First experiences with multiple bilateral insertions of a newly developed microcatheter-compatible endovascular electroencephalogram electrode for humans with epilepsy |
| title_fullStr | First experiences with multiple bilateral insertions of a newly developed microcatheter-compatible endovascular electroencephalogram electrode for humans with epilepsy |
| title_full_unstemmed | First experiences with multiple bilateral insertions of a newly developed microcatheter-compatible endovascular electroencephalogram electrode for humans with epilepsy |
| title_short | First experiences with multiple bilateral insertions of a newly developed microcatheter-compatible endovascular electroencephalogram electrode for humans with epilepsy |
| title_sort | first experiences with multiple bilateral insertions of a newly developed microcatheter compatible endovascular electroencephalogram electrode for humans with epilepsy |
| topic | Endovascular electroencephalogram electrode Epilepsy Seizure focus Microcatheter-compatible electrodes |
| url | http://www.sciencedirect.com/science/article/pii/S2589986425000085 |
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