Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model Study
Basal levels of monoamines and DHEA in four main limbic brain regions were measured in prepubertal Wistar Kyoto (WKY) rats (a putative animal model of childhood depression). Basal levels of “Brain-Derived Neurotrophic Factor (BDNF)” were also determined in two regions in the hippocampus, compared wi...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2009/405107 |
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| author | O. Malkesman T. Asaf L. Shbiro A. Goldstein R. Maayan A. Weizman N. Kinor E. Okun B. Sredni G. Yadid A. Weller |
| author_facet | O. Malkesman T. Asaf L. Shbiro A. Goldstein R. Maayan A. Weizman N. Kinor E. Okun B. Sredni G. Yadid A. Weller |
| author_sort | O. Malkesman |
| collection | DOAJ |
| description | Basal levels of monoamines and DHEA in four main limbic brain regions were measured in prepubertal Wistar Kyoto (WKY) rats (a putative animal model of childhood depression). Basal levels of “Brain-Derived Neurotrophic Factor (BDNF)” were also determined in two regions in the hippocampus, compared with Wistar strain controls. In the second phase, we examined the responsiveness of prepubertal WKY rats to different types of chronic antidepressant treatments: Fluoxetine, Desipramine, and dehydroepiandrosterone sulfate (DHEAS). WKY prepubertal rats exhibited different monoamine levels in the limbic system, reduced DHEA levels in the VTA and lower levels of BDNF in the hippocampus CA3 region compared to controls. In prepubertal WKY rats, only treatment with DHEAS produced a statistically significant decrease in immobility, compared to saline-administered controls in the forced swim test. Wistar controls were not affected by any antidepressant. The results imply that DHEA(S) and BDNF may be involved in the pathophysiology and pharmacotherapy of childhood depression. |
| format | Article |
| id | doaj-art-733f9074ae6343dfb7efa4f015aadf0a |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-733f9074ae6343dfb7efa4f015aadf0a2025-02-03T01:21:30ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422009-01-01200910.1155/2009/405107405107Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model StudyO. Malkesman0T. Asaf1L. Shbiro2A. Goldstein3R. Maayan4A. Weizman5N. Kinor6E. Okun7B. Sredni8G. Yadid9A. Weller10Interdisciplinary Program in the Brain Sciences, Bar-Ilan University, Ramat-Gan 52900, IsraelInterdisciplinary Program in the Brain Sciences, Bar-Ilan University, Ramat-Gan 52900, IsraelThe Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, IsraelThe Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, IsraelBiological Psychiatry Laboratory, Felsenstein Medical Research Center, Beilinson Campus, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49100, IsraelBiological Psychiatry Laboratory, Felsenstein Medical Research Center, Beilinson Campus, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 49100, IsraelThe Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, IsraelFaculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, IsraelFaculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, IsraelThe Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, IsraelThe Gonda (Goldschmied) Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan 52900, IsraelBasal levels of monoamines and DHEA in four main limbic brain regions were measured in prepubertal Wistar Kyoto (WKY) rats (a putative animal model of childhood depression). Basal levels of “Brain-Derived Neurotrophic Factor (BDNF)” were also determined in two regions in the hippocampus, compared with Wistar strain controls. In the second phase, we examined the responsiveness of prepubertal WKY rats to different types of chronic antidepressant treatments: Fluoxetine, Desipramine, and dehydroepiandrosterone sulfate (DHEAS). WKY prepubertal rats exhibited different monoamine levels in the limbic system, reduced DHEA levels in the VTA and lower levels of BDNF in the hippocampus CA3 region compared to controls. In prepubertal WKY rats, only treatment with DHEAS produced a statistically significant decrease in immobility, compared to saline-administered controls in the forced swim test. Wistar controls were not affected by any antidepressant. The results imply that DHEA(S) and BDNF may be involved in the pathophysiology and pharmacotherapy of childhood depression.http://dx.doi.org/10.1155/2009/405107 |
| spellingShingle | O. Malkesman T. Asaf L. Shbiro A. Goldstein R. Maayan A. Weizman N. Kinor E. Okun B. Sredni G. Yadid A. Weller Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model Study Advances in Pharmacological Sciences |
| title | Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model Study |
| title_full | Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model Study |
| title_fullStr | Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model Study |
| title_full_unstemmed | Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model Study |
| title_short | Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model Study |
| title_sort | monoamines bdnf dehydroepiandrosterone dhea sulfate and childhood depression an animal model study |
| url | http://dx.doi.org/10.1155/2009/405107 |
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