Correlation between acupuncture dose and pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review
Abstract Background Increasing studies focused on the efficacy of acupuncture on pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization-embryo transfer (IVF-ET). However, debatable conclusions have been drawn from different randomized controlled trials...
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BMC
2024-11-01
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| Series: | BMC Complementary Medicine and Therapies |
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| Online Access: | https://doi.org/10.1186/s12906-024-04695-9 |
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| author | Yi Ting Li Chao Liang Li Han Yang Lei Huang Jia Jia Liu Xiao Yan Zheng Xin Yue Tao Zheng Yu Fan Rong Liang Xiao Ping Tian Jie Yang |
| author_facet | Yi Ting Li Chao Liang Li Han Yang Lei Huang Jia Jia Liu Xiao Yan Zheng Xin Yue Tao Zheng Yu Fan Rong Liang Xiao Ping Tian Jie Yang |
| author_sort | Yi Ting Li |
| collection | DOAJ |
| description | Abstract Background Increasing studies focused on the efficacy of acupuncture on pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization-embryo transfer (IVF-ET). However, debatable conclusions have been drawn from different randomized controlled trials (RCTs), which might be related to different doses of acupuncture. Objective To evaluate whether acupuncture has a dose-dependent effect on pregnancy outcomes in patients with PCOS undergoing IVF-ET in systematically reviewing. Methods Seven electronic databases were searched from inception to October 10th, 2024. The Cochrane Collaboration’s tool ROB 2.0 (ROB 2.0) provided an assessment for the risk of bias. The acupuncture dose was extracted, then categorized into high, medium, and low dose according to the scoring system results, the evidence was assessed by Slavin’s qualitative best-evidence synthesis approach in a rigours methodological way. Clinical pregnancy rate (CPR) was regarded as the primary outcome. Results A total of 953 subjects met the eligibility criteria in 12 RCTs were included, among which two studies were low dose, four were medium dose, and six were high dose. The overall quality of included studies was low, 50.00% (6/12) studies were low risk, 16.67% (2/12) studies were some concerns, and 33.33% (4/12) studies were high risk. Comparing the results, the consistent high-dose result among high-quality trials provides strong evidence for a positive correlation between high-dose acupuncture and pregnancy outcomes. Conclusion A trend indicates that higher acupuncture doses yield better outcomes for PCOS patients undergoing IVF-ET. Further confirmation through direct comparisons of different doses was needed. Trial registration The systematic review has been registered on PROSPERO ( https://www.crd.york.ac.uk/prospero/ ), and the registration number is CRD42023400187. |
| format | Article |
| id | doaj-art-733f4b8f8f934797988099d47096dac7 |
| institution | DOAJ |
| issn | 2662-7671 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary Medicine and Therapies |
| spelling | doaj-art-733f4b8f8f934797988099d47096dac72025-08-20T02:51:42ZengBMCBMC Complementary Medicine and Therapies2662-76712024-11-0124111110.1186/s12906-024-04695-9Correlation between acupuncture dose and pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic reviewYi Ting Li0Chao Liang Li1Han Yang2Lei Huang3Jia Jia Liu4Xiao Yan Zheng5Xin Yue Tao6Zheng Yu7Fan Rong Liang8Xiao Ping Tian9Jie Yang10Acupuncture and Tuina School, Chengdu University of Traditional Chinese MedicineAcupuncture and Tuina School, Chengdu University of Traditional Chinese MedicineDivision of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan UniversityAcupuncture and Tuina School, Chengdu University of Traditional Chinese MedicineAcupuncture and Tuina School, Chengdu University of Traditional Chinese MedicineAcupuncture and Tuina School, Chengdu University of Traditional Chinese MedicineAcupuncture and Tuina School, Chengdu University of Traditional Chinese MedicineIntelligent Medicine School, Chengdu University of Traditional Chinese MedicineAcupuncture and Tuina School, Chengdu University of Traditional Chinese MedicineAcupuncture and Tuina School, Chengdu University of Traditional Chinese MedicineAcupuncture and Tuina School, Chengdu University of Traditional Chinese MedicineAbstract Background Increasing studies focused on the efficacy of acupuncture on pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization-embryo transfer (IVF-ET). However, debatable conclusions have been drawn from different randomized controlled trials (RCTs), which might be related to different doses of acupuncture. Objective To evaluate whether acupuncture has a dose-dependent effect on pregnancy outcomes in patients with PCOS undergoing IVF-ET in systematically reviewing. Methods Seven electronic databases were searched from inception to October 10th, 2024. The Cochrane Collaboration’s tool ROB 2.0 (ROB 2.0) provided an assessment for the risk of bias. The acupuncture dose was extracted, then categorized into high, medium, and low dose according to the scoring system results, the evidence was assessed by Slavin’s qualitative best-evidence synthesis approach in a rigours methodological way. Clinical pregnancy rate (CPR) was regarded as the primary outcome. Results A total of 953 subjects met the eligibility criteria in 12 RCTs were included, among which two studies were low dose, four were medium dose, and six were high dose. The overall quality of included studies was low, 50.00% (6/12) studies were low risk, 16.67% (2/12) studies were some concerns, and 33.33% (4/12) studies were high risk. Comparing the results, the consistent high-dose result among high-quality trials provides strong evidence for a positive correlation between high-dose acupuncture and pregnancy outcomes. Conclusion A trend indicates that higher acupuncture doses yield better outcomes for PCOS patients undergoing IVF-ET. Further confirmation through direct comparisons of different doses was needed. Trial registration The systematic review has been registered on PROSPERO ( https://www.crd.york.ac.uk/prospero/ ), and the registration number is CRD42023400187.https://doi.org/10.1186/s12906-024-04695-9Acupuncture therapyAcupuncture treatment dosePolycystic ovary syndrome (according to ICD-10 manual)Systematic reviewPregnancy rate |
| spellingShingle | Yi Ting Li Chao Liang Li Han Yang Lei Huang Jia Jia Liu Xiao Yan Zheng Xin Yue Tao Zheng Yu Fan Rong Liang Xiao Ping Tian Jie Yang Correlation between acupuncture dose and pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review BMC Complementary Medicine and Therapies Acupuncture therapy Acupuncture treatment dose Polycystic ovary syndrome (according to ICD-10 manual) Systematic review Pregnancy rate |
| title | Correlation between acupuncture dose and pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review |
| title_full | Correlation between acupuncture dose and pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review |
| title_fullStr | Correlation between acupuncture dose and pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review |
| title_full_unstemmed | Correlation between acupuncture dose and pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review |
| title_short | Correlation between acupuncture dose and pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization-embryo transfer: a systematic review |
| title_sort | correlation between acupuncture dose and pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization embryo transfer a systematic review |
| topic | Acupuncture therapy Acupuncture treatment dose Polycystic ovary syndrome (according to ICD-10 manual) Systematic review Pregnancy rate |
| url | https://doi.org/10.1186/s12906-024-04695-9 |
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