The Role of Lower Airway Dysbiosis in Asthma: Dysbiosis and Asthma
With the development of culture-independent techniques, numerous studies have demonstrated that the lower airway is not sterile in health and harbors diverse microbial communities. Furthermore, new evidence suggests that there is a distinct lower airway microbiome in those with chronic respiratory d...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/3890601 |
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| _version_ | 1832545791560908800 |
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| author | Junying Lu Lingxin Xiong Xiaohao Zhang Zhongmin Liu Shiji Wang Chao Zhang Jingtong Zheng Guoqiang Wang Ruipeng Zheng Jodie L. Simpson Fang Wang |
| author_facet | Junying Lu Lingxin Xiong Xiaohao Zhang Zhongmin Liu Shiji Wang Chao Zhang Jingtong Zheng Guoqiang Wang Ruipeng Zheng Jodie L. Simpson Fang Wang |
| author_sort | Junying Lu |
| collection | DOAJ |
| description | With the development of culture-independent techniques, numerous studies have demonstrated that the lower airway is not sterile in health and harbors diverse microbial communities. Furthermore, new evidence suggests that there is a distinct lower airway microbiome in those with chronic respiratory disease. To understand the role of lower airway dysbiosis in the pathogenesis of asthma, in this article, we review the published reports about the lung microbiome of healthy controls, provide an outlook on the contribution of lower airway dysbiosis to asthma, especially steroid-resistant asthma, and discuss the potential therapies targeted for lower airway dysbiosis. |
| format | Article |
| id | doaj-art-733e1a9a308342ea87732ce741bb0119 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-733e1a9a308342ea87732ce741bb01192025-02-03T07:24:45ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/38906013890601The Role of Lower Airway Dysbiosis in Asthma: Dysbiosis and AsthmaJunying Lu0Lingxin Xiong1Xiaohao Zhang2Zhongmin Liu3Shiji Wang4Chao Zhang5Jingtong Zheng6Guoqiang Wang7Ruipeng Zheng8Jodie L. Simpson9Fang Wang10Department of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Cardiology, Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Intensive Care Unit, First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Intensive Care Unit, First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaDepartment of Pathogeny Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, ChinaWith the development of culture-independent techniques, numerous studies have demonstrated that the lower airway is not sterile in health and harbors diverse microbial communities. Furthermore, new evidence suggests that there is a distinct lower airway microbiome in those with chronic respiratory disease. To understand the role of lower airway dysbiosis in the pathogenesis of asthma, in this article, we review the published reports about the lung microbiome of healthy controls, provide an outlook on the contribution of lower airway dysbiosis to asthma, especially steroid-resistant asthma, and discuss the potential therapies targeted for lower airway dysbiosis.http://dx.doi.org/10.1155/2017/3890601 |
| spellingShingle | Junying Lu Lingxin Xiong Xiaohao Zhang Zhongmin Liu Shiji Wang Chao Zhang Jingtong Zheng Guoqiang Wang Ruipeng Zheng Jodie L. Simpson Fang Wang The Role of Lower Airway Dysbiosis in Asthma: Dysbiosis and Asthma Mediators of Inflammation |
| title | The Role of Lower Airway Dysbiosis in Asthma: Dysbiosis and Asthma |
| title_full | The Role of Lower Airway Dysbiosis in Asthma: Dysbiosis and Asthma |
| title_fullStr | The Role of Lower Airway Dysbiosis in Asthma: Dysbiosis and Asthma |
| title_full_unstemmed | The Role of Lower Airway Dysbiosis in Asthma: Dysbiosis and Asthma |
| title_short | The Role of Lower Airway Dysbiosis in Asthma: Dysbiosis and Asthma |
| title_sort | role of lower airway dysbiosis in asthma dysbiosis and asthma |
| url | http://dx.doi.org/10.1155/2017/3890601 |
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