Synthesis of Dextran/Methoxy Poly(ethylene glycol) Block Copolymer
We synthesized a block copolymer composed of dextran and methoxy poly(ethylene glycol) (mPEG). To accomplish this, the end group of dextran was modified by reductive amination. The aminated dextran (Dextran-NH2) showed the intrinsic peaks of both dextran at 3~5.5 ppm and hexamethylene diamine at...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/414185 |
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| author | Young-Il Jeong Dong-Gon Kim Dae-Hwan Kang |
| author_facet | Young-Il Jeong Dong-Gon Kim Dae-Hwan Kang |
| author_sort | Young-Il Jeong |
| collection | DOAJ |
| description | We synthesized a block copolymer composed of dextran and methoxy poly(ethylene glycol) (mPEG). To accomplish this, the end group of dextran was modified by reductive amination. The aminated dextran (Dextran-NH2) showed the intrinsic peaks of both dextran at 3~5.5 ppm and hexamethylene diamine at
1~2.6 ppm at 1H nuclear magnetic resonance (NMR) spectrum. The amino end group of dextran was conjugated with mPEG to make the block copolymer consisting of dextran/mPEG (abbreviated as DexPEG). The synthesized aminated dextran and DexPEG were characterized using 1H NMR and gel permeation chromatography (GPC). The molecular weight and conjugation yield were estimated by comparing the intensity ratio of the proton peaks of the glucose molecule (4.9 ppm and 3.3~4.0 ppm) to that of the ethylene group of mPEG (3.7 ppm). Abundant hydroxyl group in the dextran chain can be used as a source of bioactive agent conjugation. |
| format | Article |
| id | doaj-art-733d9ad3aca7409e99f8b59b906c6eee |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-733d9ad3aca7409e99f8b59b906c6eee2025-08-20T03:33:50ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/414185414185Synthesis of Dextran/Methoxy Poly(ethylene glycol) Block CopolymerYoung-Il Jeong0Dong-Gon Kim1Dae-Hwan Kang2National Research and Development Center for Hepatobiliary Disease, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, Gyeongnam 626-770, Republic of KoreaUtah-Inha DDS & Advanced Therapeutics Research Center, Incheon 406-840, Republic of KoreaNational Research and Development Center for Hepatobiliary Disease, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, Gyeongnam 626-770, Republic of KoreaWe synthesized a block copolymer composed of dextran and methoxy poly(ethylene glycol) (mPEG). To accomplish this, the end group of dextran was modified by reductive amination. The aminated dextran (Dextran-NH2) showed the intrinsic peaks of both dextran at 3~5.5 ppm and hexamethylene diamine at 1~2.6 ppm at 1H nuclear magnetic resonance (NMR) spectrum. The amino end group of dextran was conjugated with mPEG to make the block copolymer consisting of dextran/mPEG (abbreviated as DexPEG). The synthesized aminated dextran and DexPEG were characterized using 1H NMR and gel permeation chromatography (GPC). The molecular weight and conjugation yield were estimated by comparing the intensity ratio of the proton peaks of the glucose molecule (4.9 ppm and 3.3~4.0 ppm) to that of the ethylene group of mPEG (3.7 ppm). Abundant hydroxyl group in the dextran chain can be used as a source of bioactive agent conjugation.http://dx.doi.org/10.1155/2013/414185 |
| spellingShingle | Young-Il Jeong Dong-Gon Kim Dae-Hwan Kang Synthesis of Dextran/Methoxy Poly(ethylene glycol) Block Copolymer Journal of Chemistry |
| title | Synthesis of Dextran/Methoxy Poly(ethylene glycol) Block Copolymer |
| title_full | Synthesis of Dextran/Methoxy Poly(ethylene glycol) Block Copolymer |
| title_fullStr | Synthesis of Dextran/Methoxy Poly(ethylene glycol) Block Copolymer |
| title_full_unstemmed | Synthesis of Dextran/Methoxy Poly(ethylene glycol) Block Copolymer |
| title_short | Synthesis of Dextran/Methoxy Poly(ethylene glycol) Block Copolymer |
| title_sort | synthesis of dextran methoxy poly ethylene glycol block copolymer |
| url | http://dx.doi.org/10.1155/2013/414185 |
| work_keys_str_mv | AT youngiljeong synthesisofdextranmethoxypolyethyleneglycolblockcopolymer AT donggonkim synthesisofdextranmethoxypolyethyleneglycolblockcopolymer AT daehwankang synthesisofdextranmethoxypolyethyleneglycolblockcopolymer |