Salivary biomarkers: A promising avenue for advancing oral cancer detection
Salivary cancer biomarkers are crucial for the earliest identification of oral carcinoma, particularly oral squamous cell carcinoma (OSCC). This article will address recent progress in detecting saliva biomarkers including human DNA, mRNA and proteins that can be of diagnostic value in cancer. Post-...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024001614 |
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| author | Yuvashree Chandrasekaran L. Kayal N. Aravindha Babu Mukesh Kumar Dharmalingam Jothinathan Archana Behera |
| author_facet | Yuvashree Chandrasekaran L. Kayal N. Aravindha Babu Mukesh Kumar Dharmalingam Jothinathan Archana Behera |
| author_sort | Yuvashree Chandrasekaran |
| collection | DOAJ |
| description | Salivary cancer biomarkers are crucial for the earliest identification of oral carcinoma, particularly oral squamous cell carcinoma (OSCC). This article will address recent progress in detecting saliva biomarkers including human DNA, mRNA and proteins that can be of diagnostic value in cancer. Post-genome studies have discovered molecular mutations that can be used to track OSCC progress and biomarkers containing actin and myosin it. Although some problems like RNA degradation and different variations of biomolecules still linger, saliva-based diagnostics provide a non-invasive and inexpensive mode of access to healthcare. The development of the detailed process of sample collection and biomarker validation as well as standardization is extremely important for the common clinical application. Moreover, the study of circular RNAs and non-coding RNAs in the saliva indicates the outlook for the improvement of diagnostics precision in the years ahead. Working hand in hand with various research teams is paramount to solving special technology problems and improving saliva testing methods. On the whole, saliva biomarkers represent a great promise to make a solid impact on cancer screening, early detection, and a much-improved patient outcome in oral cancer treatment. |
| format | Article |
| id | doaj-art-7339927339ce45919a3abfb2a58b9baf |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-7339927339ce45919a3abfb2a58b9baf2025-01-09T06:15:47ZengElsevierOral Oncology Reports2772-90602024-06-0110100315Salivary biomarkers: A promising avenue for advancing oral cancer detectionYuvashree Chandrasekaran0L. Kayal1N. Aravindha Babu2Mukesh Kumar Dharmalingam Jothinathan3Archana Behera4Centre for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, IndiaGovt. Stanley Medical College, The TN DR MGR Medical University, Chennai 600001, IndiaDepartment of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research (BIHER), Bharath University, Chennai, Tamil Nadu, IndiaCorresponding author.; Centre for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, IndiaCentre for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, IndiaSalivary cancer biomarkers are crucial for the earliest identification of oral carcinoma, particularly oral squamous cell carcinoma (OSCC). This article will address recent progress in detecting saliva biomarkers including human DNA, mRNA and proteins that can be of diagnostic value in cancer. Post-genome studies have discovered molecular mutations that can be used to track OSCC progress and biomarkers containing actin and myosin it. Although some problems like RNA degradation and different variations of biomolecules still linger, saliva-based diagnostics provide a non-invasive and inexpensive mode of access to healthcare. The development of the detailed process of sample collection and biomarker validation as well as standardization is extremely important for the common clinical application. Moreover, the study of circular RNAs and non-coding RNAs in the saliva indicates the outlook for the improvement of diagnostics precision in the years ahead. Working hand in hand with various research teams is paramount to solving special technology problems and improving saliva testing methods. On the whole, saliva biomarkers represent a great promise to make a solid impact on cancer screening, early detection, and a much-improved patient outcome in oral cancer treatment.http://www.sciencedirect.com/science/article/pii/S2772906024001614Saliva biomarkersOral cancerMolecular diagnosticsProteomicsEarly detection |
| spellingShingle | Yuvashree Chandrasekaran L. Kayal N. Aravindha Babu Mukesh Kumar Dharmalingam Jothinathan Archana Behera Salivary biomarkers: A promising avenue for advancing oral cancer detection Oral Oncology Reports Saliva biomarkers Oral cancer Molecular diagnostics Proteomics Early detection |
| title | Salivary biomarkers: A promising avenue for advancing oral cancer detection |
| title_full | Salivary biomarkers: A promising avenue for advancing oral cancer detection |
| title_fullStr | Salivary biomarkers: A promising avenue for advancing oral cancer detection |
| title_full_unstemmed | Salivary biomarkers: A promising avenue for advancing oral cancer detection |
| title_short | Salivary biomarkers: A promising avenue for advancing oral cancer detection |
| title_sort | salivary biomarkers a promising avenue for advancing oral cancer detection |
| topic | Saliva biomarkers Oral cancer Molecular diagnostics Proteomics Early detection |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024001614 |
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