Impact of SGLT-2 Inhibitors on Biomarkers of Heart Failure
Type 2 diabetes mellitus affects nearly 7% of the world’s population and is a significant contributor to the development of cardiovascular disease and heart failure. Historically, the pharmacologic therapy of cardiovascular disease has centered around blood pressure control, insulin and cholesterol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/12/919 |
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| author | Dana Darwish Pooja Kumar Khushi Urs Siddharth Dave |
| author_facet | Dana Darwish Pooja Kumar Khushi Urs Siddharth Dave |
| author_sort | Dana Darwish |
| collection | DOAJ |
| description | Type 2 diabetes mellitus affects nearly 7% of the world’s population and is a significant contributor to the development of cardiovascular disease and heart failure. Historically, the pharmacologic therapy of cardiovascular disease has centered around blood pressure control, insulin and cholesterol management, the inhibition of the renin–angiotensin system, and catecholamine blockade. Recent evidence suggests that sodium–glucose cotransporter 2 (SGLT-2) inhibitors provide significant cardiovascular protection to patients with and without diabetes. The use of SGLT-2 inhibitors is associated with significant changes to serum biomarkers of cardiac function. In this narrative review, we summarize how biomarkers reflect physiologic aspects of cardiovascular function and how these are affected by the use of SGLT-2 inhibitors. |
| format | Article |
| id | doaj-art-7338da62b4284beaa792806bc2f3308b |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-7338da62b4284beaa792806bc2f3308b2025-08-20T03:26:20ZengMDPI AGCells2073-44092025-06-01141291910.3390/cells14120919Impact of SGLT-2 Inhibitors on Biomarkers of Heart FailureDana Darwish0Pooja Kumar1Khushi Urs2Siddharth Dave3Department of Anesthesiology and Pain Medicine, University of Texas Southwestern, Dallas, TX 75390, USASchool of Medicine, University of Texas Southwestern, Dallas, TX 75390, USAUniversity of Texas Southwestern Medical Center, Dallas, TX 75390, USADepartment of Anesthesiology and Pain Medicine, University of Texas Southwestern, Dallas, TX 75390, USAType 2 diabetes mellitus affects nearly 7% of the world’s population and is a significant contributor to the development of cardiovascular disease and heart failure. Historically, the pharmacologic therapy of cardiovascular disease has centered around blood pressure control, insulin and cholesterol management, the inhibition of the renin–angiotensin system, and catecholamine blockade. Recent evidence suggests that sodium–glucose cotransporter 2 (SGLT-2) inhibitors provide significant cardiovascular protection to patients with and without diabetes. The use of SGLT-2 inhibitors is associated with significant changes to serum biomarkers of cardiac function. In this narrative review, we summarize how biomarkers reflect physiologic aspects of cardiovascular function and how these are affected by the use of SGLT-2 inhibitors.https://www.mdpi.com/2073-4409/14/12/919SGLT-2 inhibitorsheart failurediabetes mellituscardiac biomarkers |
| spellingShingle | Dana Darwish Pooja Kumar Khushi Urs Siddharth Dave Impact of SGLT-2 Inhibitors on Biomarkers of Heart Failure Cells SGLT-2 inhibitors heart failure diabetes mellitus cardiac biomarkers |
| title | Impact of SGLT-2 Inhibitors on Biomarkers of Heart Failure |
| title_full | Impact of SGLT-2 Inhibitors on Biomarkers of Heart Failure |
| title_fullStr | Impact of SGLT-2 Inhibitors on Biomarkers of Heart Failure |
| title_full_unstemmed | Impact of SGLT-2 Inhibitors on Biomarkers of Heart Failure |
| title_short | Impact of SGLT-2 Inhibitors on Biomarkers of Heart Failure |
| title_sort | impact of sglt 2 inhibitors on biomarkers of heart failure |
| topic | SGLT-2 inhibitors heart failure diabetes mellitus cardiac biomarkers |
| url | https://www.mdpi.com/2073-4409/14/12/919 |
| work_keys_str_mv | AT danadarwish impactofsglt2inhibitorsonbiomarkersofheartfailure AT poojakumar impactofsglt2inhibitorsonbiomarkersofheartfailure AT khushiurs impactofsglt2inhibitorsonbiomarkersofheartfailure AT siddharthdave impactofsglt2inhibitorsonbiomarkersofheartfailure |