A Comparison Study of Olmesartan and Valsartan Effects on Myocardial Metabolism in Patients With Dilated Cardiomyopathy: the OVOID Trial
Background Myocardial metabolism plays an important role in maintaining cardiac function. Patients with dilated cardiomyopathy exhibit alterations in myocardial metabolism characterized by increased myocardial glucose metabolism. This study aimed to evaluate effects on myocardial metabolism of the a...
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Wiley
2025-07-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.125.041406 |
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| author | Sangyong Jo Kyungil Park Jae Hyuk Choi Chang‐Bae Sohn Jeonghwan Kim Yong‐Seop Kwon Su Hong Kim Tae‐ho Park |
| author_facet | Sangyong Jo Kyungil Park Jae Hyuk Choi Chang‐Bae Sohn Jeonghwan Kim Yong‐Seop Kwon Su Hong Kim Tae‐ho Park |
| author_sort | Sangyong Jo |
| collection | DOAJ |
| description | Background Myocardial metabolism plays an important role in maintaining cardiac function. Patients with dilated cardiomyopathy exhibit alterations in myocardial metabolism characterized by increased myocardial glucose metabolism. This study aimed to evaluate effects on myocardial metabolism of the angiotensin II receptor blockers olmesartan and valsartan in patients with dilated cardiomyopathy. We hypothesized that olmesartan, owing to its stronger and longer‐lasting angiotensin II receptor blockade, would lead to a greater reduction in myocardial glucose metabolism compared with valsartan. Methods OVOID (A Comparison Study of Olmesartan and Valsartan Effects on Myocardial Metabolism in Patients With Dilated Cardiomyopathy) was a multicenter, randomized controlled trial involving 44 patients with New York Heart Association classes II through IV dilated cardiomyopathy. Participants were randomized 1:1 to receive olmesartan (20 mg once daily) or valsartan (160 mg twice daily) for 6 months, in addition to standard care. The primary outcome was myocardial glucose metabolism measured by standardized uptake value ratio at 6 months after treatment. To measure standardized uptake value ratio, 18F‐fluoro‐2‐deoxyglucose cardiac positron emission tomography was performed at baseline and 6 months after receiving the study agent. Results Baseline clinical characteristics and standardized uptake value ratio were not significantly different between the 2 groups. The average left ventricular ejection fraction was 25.1%±7.8% at baseline, with significant improvement in both groups after 6 months, though with no difference between them. At 6 months, the standardized uptake value ratio value was significantly lower in the olmesartan group than that in the valsartan (3.76±2.00 versus 5.76±3.10; P=0.01). Conclusions Six months of olmesartan therapy significantly decreased myocardial glucose metabolism in dilated cardiomyopathy patients compared with valsartan therapy for 6 months. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT04174456. |
| format | Article |
| id | doaj-art-73361d69d24a440f86866ca4f2c2df2a |
| institution | Kabale University |
| issn | 2047-9980 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-73361d69d24a440f86866ca4f2c2df2a2025-08-20T03:34:45ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802025-07-01141310.1161/JAHA.125.041406A Comparison Study of Olmesartan and Valsartan Effects on Myocardial Metabolism in Patients With Dilated Cardiomyopathy: the OVOID TrialSangyong Jo0Kyungil Park1Jae Hyuk Choi2Chang‐Bae Sohn3Jeonghwan Kim4Yong‐Seop Kwon5Su Hong Kim6Tae‐ho Park7Division of Cardiology, Department of Internal Medicine, Regional Cardiocerebrovascular Center Dong‐A University Hospital Busan Republic of KoreaDivision of Cardiology, Department of Internal Medicine, Regional Cardiocerebrovascular Center Dong‐A University Hospital Busan Republic of KoreaGimhaebokum Hospital Gimhae Republic of KoreaUlsan Medical Center Ulsan Republic of KoreaDong‐eui Hospital Busan Republic of KoreaBusan St.Mary’s Hospital Busan Republic of KoreaBusan Veterans Hospital Busan Republic of KoreaDivision of Cardiology, Department of Internal Medicine, Regional Cardiocerebrovascular Center Dong‐A University Hospital Busan Republic of KoreaBackground Myocardial metabolism plays an important role in maintaining cardiac function. Patients with dilated cardiomyopathy exhibit alterations in myocardial metabolism characterized by increased myocardial glucose metabolism. This study aimed to evaluate effects on myocardial metabolism of the angiotensin II receptor blockers olmesartan and valsartan in patients with dilated cardiomyopathy. We hypothesized that olmesartan, owing to its stronger and longer‐lasting angiotensin II receptor blockade, would lead to a greater reduction in myocardial glucose metabolism compared with valsartan. Methods OVOID (A Comparison Study of Olmesartan and Valsartan Effects on Myocardial Metabolism in Patients With Dilated Cardiomyopathy) was a multicenter, randomized controlled trial involving 44 patients with New York Heart Association classes II through IV dilated cardiomyopathy. Participants were randomized 1:1 to receive olmesartan (20 mg once daily) or valsartan (160 mg twice daily) for 6 months, in addition to standard care. The primary outcome was myocardial glucose metabolism measured by standardized uptake value ratio at 6 months after treatment. To measure standardized uptake value ratio, 18F‐fluoro‐2‐deoxyglucose cardiac positron emission tomography was performed at baseline and 6 months after receiving the study agent. Results Baseline clinical characteristics and standardized uptake value ratio were not significantly different between the 2 groups. The average left ventricular ejection fraction was 25.1%±7.8% at baseline, with significant improvement in both groups after 6 months, though with no difference between them. At 6 months, the standardized uptake value ratio value was significantly lower in the olmesartan group than that in the valsartan (3.76±2.00 versus 5.76±3.10; P=0.01). Conclusions Six months of olmesartan therapy significantly decreased myocardial glucose metabolism in dilated cardiomyopathy patients compared with valsartan therapy for 6 months. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT04174456.https://www.ahajournals.org/doi/10.1161/JAHA.125.041406myocardial metabolismolmesartanpositron emission tomographyvalsartan |
| spellingShingle | Sangyong Jo Kyungil Park Jae Hyuk Choi Chang‐Bae Sohn Jeonghwan Kim Yong‐Seop Kwon Su Hong Kim Tae‐ho Park A Comparison Study of Olmesartan and Valsartan Effects on Myocardial Metabolism in Patients With Dilated Cardiomyopathy: the OVOID Trial Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease myocardial metabolism olmesartan positron emission tomography valsartan |
| title | A Comparison Study of Olmesartan and Valsartan Effects on Myocardial Metabolism in Patients With Dilated Cardiomyopathy: the OVOID Trial |
| title_full | A Comparison Study of Olmesartan and Valsartan Effects on Myocardial Metabolism in Patients With Dilated Cardiomyopathy: the OVOID Trial |
| title_fullStr | A Comparison Study of Olmesartan and Valsartan Effects on Myocardial Metabolism in Patients With Dilated Cardiomyopathy: the OVOID Trial |
| title_full_unstemmed | A Comparison Study of Olmesartan and Valsartan Effects on Myocardial Metabolism in Patients With Dilated Cardiomyopathy: the OVOID Trial |
| title_short | A Comparison Study of Olmesartan and Valsartan Effects on Myocardial Metabolism in Patients With Dilated Cardiomyopathy: the OVOID Trial |
| title_sort | comparison study of olmesartan and valsartan effects on myocardial metabolism in patients with dilated cardiomyopathy the ovoid trial |
| topic | myocardial metabolism olmesartan positron emission tomography valsartan |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.125.041406 |
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