Prevalence and incidence of celiac disease in patients with rheumatoid arthritis: a case-control study based on the RECORD cohort
BackgroundThe reported prevalence of coeliac disease (CD) in rheumatoid arthritis (RA) is variable.ObjectiveTo evaluate the prevalence and incidence of CD in RA and controls.DesignCase-control study on administrative data.MethodsThe RECord linkage On Rheumatic Disease database (administrative data,...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1470855/full |
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| author | Garifallia Sakellariou Garifallia Sakellariou Annalisa Schiepatti Annalisa Schiepatti Anna Zanetti Carlomaurizio Montecucco Carlomaurizio Montecucco Federico Biagi Federico Biagi Carlo Alberto Scirè Carlo Alberto Scirè |
| author_facet | Garifallia Sakellariou Garifallia Sakellariou Annalisa Schiepatti Annalisa Schiepatti Anna Zanetti Carlomaurizio Montecucco Carlomaurizio Montecucco Federico Biagi Federico Biagi Carlo Alberto Scirè Carlo Alberto Scirè |
| author_sort | Garifallia Sakellariou |
| collection | DOAJ |
| description | BackgroundThe reported prevalence of coeliac disease (CD) in rheumatoid arthritis (RA) is variable.ObjectiveTo evaluate the prevalence and incidence of CD in RA and controls.DesignCase-control study on administrative data.MethodsThe RECord linkage On Rheumatic Disease database (administrative data, 2004–2013) was used to retrieve patients with RA and age and sex-matched controls. Prevalence and incidence of CD were calculated and stratified according to age, gender, and calendar year.ResultsThe cohort included 346,956 subjects (mean age 59.9 (14.5), 70.7% females), of which 70,061 RA and 276,895 controls. Median follow-up was 9 years (IQR 9–9). The prevalence of CD was higher in RA (171/70,061 = 0.24% (0.2–0.3%) vs 398/276895 = 0.14% (0.1–0.2%), p < 0.001). The prevalence of CD among females with RA was increased compared to controls (0.3% vs 0.08%, p < 0.001), but was not increased in males with RA. The incidence was higher in RA and remained stable throughout the observation period.ConclusionThe prevalence and incidence of CD were increased in RA, particularly in females. |
| format | Article |
| id | doaj-art-733148b6153841b1b2a4acfd8a129652 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-733148b6153841b1b2a4acfd8a1296522025-01-20T07:19:39ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.14708551470855Prevalence and incidence of celiac disease in patients with rheumatoid arthritis: a case-control study based on the RECORD cohortGarifallia Sakellariou0Garifallia Sakellariou1Annalisa Schiepatti2Annalisa Schiepatti3Anna Zanetti4Carlomaurizio Montecucco5Carlomaurizio Montecucco6Federico Biagi7Federico Biagi8Carlo Alberto Scirè9Carlo Alberto Scirè10Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, ItalyIstituti Clinici Scientifici Maugeri IRCCS, Pavia, ItalyDepartment of Internal Medicine and Therapeutics, Università di Pavia, Pavia, ItalyGastroenterology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, ItalyEpidemiology Research Unit, Italian Society for Rheumatology, Milan, ItalyDepartment of Internal Medicine and Therapeutics, Università di Pavia, Pavia, ItalyDivision of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of Internal Medicine and Therapeutics, Università di Pavia, Pavia, ItalyGastroenterology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, ItalyEpidemiology Research Unit, Italian Society for Rheumatology, Milan, ItalySchool of Medicine, University of Milano Bicocca, Milan, ItalyBackgroundThe reported prevalence of coeliac disease (CD) in rheumatoid arthritis (RA) is variable.ObjectiveTo evaluate the prevalence and incidence of CD in RA and controls.DesignCase-control study on administrative data.MethodsThe RECord linkage On Rheumatic Disease database (administrative data, 2004–2013) was used to retrieve patients with RA and age and sex-matched controls. Prevalence and incidence of CD were calculated and stratified according to age, gender, and calendar year.ResultsThe cohort included 346,956 subjects (mean age 59.9 (14.5), 70.7% females), of which 70,061 RA and 276,895 controls. Median follow-up was 9 years (IQR 9–9). The prevalence of CD was higher in RA (171/70,061 = 0.24% (0.2–0.3%) vs 398/276895 = 0.14% (0.1–0.2%), p < 0.001). The prevalence of CD among females with RA was increased compared to controls (0.3% vs 0.08%, p < 0.001), but was not increased in males with RA. The incidence was higher in RA and remained stable throughout the observation period.ConclusionThe prevalence and incidence of CD were increased in RA, particularly in females.https://www.frontiersin.org/articles/10.3389/fmed.2024.1470855/fullrheumatoid arthritiscoeliac diseaseepidemiologycomorbiditydisability |
| spellingShingle | Garifallia Sakellariou Garifallia Sakellariou Annalisa Schiepatti Annalisa Schiepatti Anna Zanetti Carlomaurizio Montecucco Carlomaurizio Montecucco Federico Biagi Federico Biagi Carlo Alberto Scirè Carlo Alberto Scirè Prevalence and incidence of celiac disease in patients with rheumatoid arthritis: a case-control study based on the RECORD cohort Frontiers in Medicine rheumatoid arthritis coeliac disease epidemiology comorbidity disability |
| title | Prevalence and incidence of celiac disease in patients with rheumatoid arthritis: a case-control study based on the RECORD cohort |
| title_full | Prevalence and incidence of celiac disease in patients with rheumatoid arthritis: a case-control study based on the RECORD cohort |
| title_fullStr | Prevalence and incidence of celiac disease in patients with rheumatoid arthritis: a case-control study based on the RECORD cohort |
| title_full_unstemmed | Prevalence and incidence of celiac disease in patients with rheumatoid arthritis: a case-control study based on the RECORD cohort |
| title_short | Prevalence and incidence of celiac disease in patients with rheumatoid arthritis: a case-control study based on the RECORD cohort |
| title_sort | prevalence and incidence of celiac disease in patients with rheumatoid arthritis a case control study based on the record cohort |
| topic | rheumatoid arthritis coeliac disease epidemiology comorbidity disability |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1470855/full |
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