Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex

Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex

SYNGAP1 haploinsufficiency-related intellectual disability (SYNGAP1-ID) is characterized by moderate to severe ID, generalized epilepsy, autism spectrum disorder, sensory processing dysfunction, and other behavioral abnormalities. While numerous studies have highlighted a role of Syngap1 in cortical...

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Bibliographic Details
Main Authors: Ruggiero Francavilla, Bidisha Chattopadhyaya, Jorelle Linda Damo Kamda, Vidya Jadhav, Said Kourrich, Jacques L Michaud, Graziella Di Cristo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-08-01
Series:eLife
Subjects:
intrinsic properties
cortical GABAergic interneurons
glutamatergic synapses
auditory cortex
Syngap1
Online Access:https://elifesciences.org/articles/97100
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https://elifesciences.org/articles/97100

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