Are probiotics useful in the treatment of chronic idiopathic constipation in adults? A review of existing systematic reviews, meta-analyses, and recommendations
Chronic idiopathic constipation (CIC) has emerged as common problem for contemporary gastroenterology and is one of the most frequent complaints in primary care. Chronic idiopathic constipation significantly affects patients’ quality of life and has an impact on global health and economy. Functional...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2019-07-01
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| Series: | Gastroenterology Review |
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| Online Access: | https://www.termedia.pl/Are-probiotics-useful-in-the-treatment-of-chronic-idiopathic-constipation-in-adults-A-review-of-existing-systematic-reviews-meta-analyses-and-recommendations,41,37246,1,1.html |
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| author | Mikołaj Kamiński Karolina Skonieczna-Żydecka Igor Łoniewski Anastasios Koulaouzidis Wojciech Marlicz |
| author_facet | Mikołaj Kamiński Karolina Skonieczna-Żydecka Igor Łoniewski Anastasios Koulaouzidis Wojciech Marlicz |
| author_sort | Mikołaj Kamiński |
| collection | DOAJ |
| description | Chronic idiopathic constipation (CIC) has emerged as common problem for contemporary gastroenterology and is one of the most frequent complaints in primary care. Chronic idiopathic constipation significantly affects patients’ quality of life and has an impact on global health and economy. Functional gastrointestinal disorders and bowel disorders, according to Rome IV criteria, result from inappropriate gut-brain interactions. The pathophysiology is complex and poorly understood, with evidence accumulating that gut microbiota can be implicated in the development and function of the enteric nervous system. Gut bacteria modulate gut barrier function, short chain fatty acid synthesis, and bile acid metabolism, factors which play roles in the gut peristalsis regulation. The high prevalence of CIC, with poor treatment outcomes, warrants searches for new forms of therapy, including probiotic therapies. Probiotics are often recommended by medical practitioners, but evidence-based utility in adults with CIC is uncertain. Recommendations/guidelines are often based on results from individual studies, rather than meta-analyses or umbrella reviews. Additionally, meta-analyses often indicate a group of probiotics rather than individual strains, and they create difficulty for physicians in making therapeutic choices. More CIC patient randomised clinical studies utilising well-defined strains, or combinations, are necessary. |
| format | Article |
| id | doaj-art-7328c2bda09c426696ece3de677c1e27 |
| institution | DOAJ |
| issn | 1895-5770 1897-4317 |
| language | English |
| publishDate | 2019-07-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Gastroenterology Review |
| spelling | doaj-art-7328c2bda09c426696ece3de677c1e272025-08-20T02:47:51ZengTermedia Publishing HouseGastroenterology Review1895-57701897-43172019-07-0115210311810.5114/pg.2019.8674737246Are probiotics useful in the treatment of chronic idiopathic constipation in adults? A review of existing systematic reviews, meta-analyses, and recommendationsMikołaj KamińskiKarolina Skonieczna-ŻydeckaIgor ŁoniewskiAnastasios KoulaouzidisWojciech MarliczChronic idiopathic constipation (CIC) has emerged as common problem for contemporary gastroenterology and is one of the most frequent complaints in primary care. Chronic idiopathic constipation significantly affects patients’ quality of life and has an impact on global health and economy. Functional gastrointestinal disorders and bowel disorders, according to Rome IV criteria, result from inappropriate gut-brain interactions. The pathophysiology is complex and poorly understood, with evidence accumulating that gut microbiota can be implicated in the development and function of the enteric nervous system. Gut bacteria modulate gut barrier function, short chain fatty acid synthesis, and bile acid metabolism, factors which play roles in the gut peristalsis regulation. The high prevalence of CIC, with poor treatment outcomes, warrants searches for new forms of therapy, including probiotic therapies. Probiotics are often recommended by medical practitioners, but evidence-based utility in adults with CIC is uncertain. Recommendations/guidelines are often based on results from individual studies, rather than meta-analyses or umbrella reviews. Additionally, meta-analyses often indicate a group of probiotics rather than individual strains, and they create difficulty for physicians in making therapeutic choices. More CIC patient randomised clinical studies utilising well-defined strains, or combinations, are necessary.https://www.termedia.pl/Are-probiotics-useful-in-the-treatment-of-chronic-idiopathic-constipation-in-adults-A-review-of-existing-systematic-reviews-meta-analyses-and-recommendations,41,37246,1,1.htmlchronic idiopathic constipation irritable bowel syndrome meta-analysis microbiota probiotics recommendations systematic review |
| spellingShingle | Mikołaj Kamiński Karolina Skonieczna-Żydecka Igor Łoniewski Anastasios Koulaouzidis Wojciech Marlicz Are probiotics useful in the treatment of chronic idiopathic constipation in adults? A review of existing systematic reviews, meta-analyses, and recommendations Gastroenterology Review chronic idiopathic constipation irritable bowel syndrome meta-analysis microbiota probiotics recommendations systematic review |
| title | Are probiotics useful in the treatment of chronic idiopathic constipation in adults? A review of existing systematic reviews, meta-analyses, and recommendations |
| title_full | Are probiotics useful in the treatment of chronic idiopathic constipation in adults? A review of existing systematic reviews, meta-analyses, and recommendations |
| title_fullStr | Are probiotics useful in the treatment of chronic idiopathic constipation in adults? A review of existing systematic reviews, meta-analyses, and recommendations |
| title_full_unstemmed | Are probiotics useful in the treatment of chronic idiopathic constipation in adults? A review of existing systematic reviews, meta-analyses, and recommendations |
| title_short | Are probiotics useful in the treatment of chronic idiopathic constipation in adults? A review of existing systematic reviews, meta-analyses, and recommendations |
| title_sort | are probiotics useful in the treatment of chronic idiopathic constipation in adults a review of existing systematic reviews meta analyses and recommendations |
| topic | chronic idiopathic constipation irritable bowel syndrome meta-analysis microbiota probiotics recommendations systematic review |
| url | https://www.termedia.pl/Are-probiotics-useful-in-the-treatment-of-chronic-idiopathic-constipation-in-adults-A-review-of-existing-systematic-reviews-meta-analyses-and-recommendations,41,37246,1,1.html |
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