Mitochondrial dysfunction in diabetic ulcers: pathophysiological mechanisms and targeted therapeutic strategies

Mitochondrial dysfunction in diabetic ulcers: pathophysiological mechanisms and targeted therapeutic strategies

Diabetic foot ulcers (DFUs) are a serious complication of diabetes, characterized by delayed wound healing, recurrent infection, and risk of amputation. Mitochondrial dysfunction has emerged as a central pathological mechanism underlying impaired wound healing. Persistent hyperglycemia triggers a ca...

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Main Authors: Yu Pan, Lin Chen, Yan Chen, Elizabeth Rosalind Thomas, Shiying Zhou, You Yang, Kezhi Liu, Jianming Wu, Xiang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
diabetes
mitochondria
trauma
apoptosis
ROS
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1625474/full
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