Biological Functions of Interleukin-21 and Its Role in Inflammation
Interleukin-21 (IL-21), the most recently discovered CD132-dependent cytokine, is mainly produced by activated T lymphocytes, particularly the inflammatory Th17 subset, and is believed to be a key factor in the transition between innate and acquired immunity. In the last few years, this cytokine has...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.275 |
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| _version_ | 1849414493202808832 |
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| author | Martin Pelletier Denis Girard |
| author_facet | Martin Pelletier Denis Girard |
| author_sort | Martin Pelletier |
| collection | DOAJ |
| description | Interleukin-21 (IL-21), the most recently discovered CD132-dependent cytokine, is mainly produced by activated T lymphocytes, particularly the inflammatory Th17 subset, and is believed to be a key factor in the transition between innate and acquired immunity. In the last few years, this cytokine has been shown to modulate the functions of T, B, and NK cells, as well as cells of myeloid origin. In addition, it was demonstrated that IL-21 is a potent antitumor agent, making it a promising candidate for the development of therapeutic tools. IL-21 has also been associated with different autoimmune and inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. This review will summarize the biological functions of IL-21 and its potential role in inflammation. |
| format | Article |
| id | doaj-art-7326ee486eba429fb555ada2bb981e6c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7326ee486eba429fb555ada2bb981e6c2025-08-20T03:33:50ZengWileyThe Scientific World Journal1537-744X2007-01-0171715173510.1100/tsw.2007.275Biological Functions of Interleukin-21 and Its Role in InflammationMartin Pelletier0Denis Girard1Department of Pathology, Division of General Pathology, University of Verona, ItalyINRS-Institut Armand-Frappier, Pointe-Claire, Québec, CanadaInterleukin-21 (IL-21), the most recently discovered CD132-dependent cytokine, is mainly produced by activated T lymphocytes, particularly the inflammatory Th17 subset, and is believed to be a key factor in the transition between innate and acquired immunity. In the last few years, this cytokine has been shown to modulate the functions of T, B, and NK cells, as well as cells of myeloid origin. In addition, it was demonstrated that IL-21 is a potent antitumor agent, making it a promising candidate for the development of therapeutic tools. IL-21 has also been associated with different autoimmune and inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. This review will summarize the biological functions of IL-21 and its potential role in inflammation.http://dx.doi.org/10.1100/tsw.2007.275 |
| spellingShingle | Martin Pelletier Denis Girard Biological Functions of Interleukin-21 and Its Role in Inflammation The Scientific World Journal |
| title | Biological Functions of Interleukin-21 and Its Role in Inflammation |
| title_full | Biological Functions of Interleukin-21 and Its Role in Inflammation |
| title_fullStr | Biological Functions of Interleukin-21 and Its Role in Inflammation |
| title_full_unstemmed | Biological Functions of Interleukin-21 and Its Role in Inflammation |
| title_short | Biological Functions of Interleukin-21 and Its Role in Inflammation |
| title_sort | biological functions of interleukin 21 and its role in inflammation |
| url | http://dx.doi.org/10.1100/tsw.2007.275 |
| work_keys_str_mv | AT martinpelletier biologicalfunctionsofinterleukin21anditsroleininflammation AT denisgirard biologicalfunctionsofinterleukin21anditsroleininflammation |