Serum Cotinine Levels and Prehypertension in Never Smokers
Background. Few studies have shown that self-reported secondhand smoke exposure in never smokers is associated with high blood pressure. However, there are no studies investigating the relationship between secondhand smoke exposure, measured objectively by serum cotinine levels, and high blood press...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2013/284524 |
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| _version_ | 1832549860055711744 |
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| author | Omayma Alshaarawy Jie Xiao Michael E. Andrew Cecil Burchfiel Anoop Shankar |
| author_facet | Omayma Alshaarawy Jie Xiao Michael E. Andrew Cecil Burchfiel Anoop Shankar |
| author_sort | Omayma Alshaarawy |
| collection | DOAJ |
| description | Background. Few studies have shown that self-reported secondhand smoke exposure in never smokers is associated with high blood pressure. However, there are no studies investigating the relationship between secondhand smoke exposure, measured objectively by serum cotinine levels, and high blood pressure in never smokers.
Methods. We examined never smokers (n=2027) from the National Health and Nutrition Examination Survey 2005–2008. Our exposure of interest was the secondhand smoke exposure estimated by serum cotinine level and our outcome was prehypertension (n=734), defined as a systolic blood pressure of 120–139 mmHg or diastolic blood pressure of 80–89 mmHg. Results. We found that, in never smokers, serum cotinine levels were positively associated with prehypertension. Compared to those with cotinine levels in the lowest quartile (≤0.024 ng/mL), the multivariable odds ratio (95% confidence interval) of prehypertension among those with cotinine levels in the highest quartile (≥0.224 ng/mL) was 1.45(1.00, 2.11); P trend =0.0451. In subsequent subgroup analyses, the positive association was found to be stronger among men, non-Whites, and non-obese subjects. Conclusion. Higher secondhand smoke exposure measured objectively by serum cotinine levels was found to be associated with prehypertension in certain subgroups of a representative sample of the US population. |
| format | Article |
| id | doaj-art-7322aaf1d8594e36879c934f799e8fd7 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-7322aaf1d8594e36879c934f799e8fd72025-02-03T06:08:20ZengWileyInternational Journal of Hypertension2090-03842090-03922013-01-01201310.1155/2013/284524284524Serum Cotinine Levels and Prehypertension in Never SmokersOmayma Alshaarawy0Jie Xiao1Michael E. Andrew2Cecil Burchfiel3Anoop Shankar4Department of Epidemiology, West Virginia University School of Public Health, 1 Medical Center Drive, P.O. Box 9190, Morgantown, WV 26506, USADepartment of Epidemiology, West Virginia University School of Public Health, 1 Medical Center Drive, P.O. Box 9190, Morgantown, WV 26506, USABiostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USABiostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USADepartment of Epidemiology, West Virginia University School of Public Health, 1 Medical Center Drive, P.O. Box 9190, Morgantown, WV 26506, USABackground. Few studies have shown that self-reported secondhand smoke exposure in never smokers is associated with high blood pressure. However, there are no studies investigating the relationship between secondhand smoke exposure, measured objectively by serum cotinine levels, and high blood pressure in never smokers. Methods. We examined never smokers (n=2027) from the National Health and Nutrition Examination Survey 2005–2008. Our exposure of interest was the secondhand smoke exposure estimated by serum cotinine level and our outcome was prehypertension (n=734), defined as a systolic blood pressure of 120–139 mmHg or diastolic blood pressure of 80–89 mmHg. Results. We found that, in never smokers, serum cotinine levels were positively associated with prehypertension. Compared to those with cotinine levels in the lowest quartile (≤0.024 ng/mL), the multivariable odds ratio (95% confidence interval) of prehypertension among those with cotinine levels in the highest quartile (≥0.224 ng/mL) was 1.45(1.00, 2.11); P trend =0.0451. In subsequent subgroup analyses, the positive association was found to be stronger among men, non-Whites, and non-obese subjects. Conclusion. Higher secondhand smoke exposure measured objectively by serum cotinine levels was found to be associated with prehypertension in certain subgroups of a representative sample of the US population.http://dx.doi.org/10.1155/2013/284524 |
| spellingShingle | Omayma Alshaarawy Jie Xiao Michael E. Andrew Cecil Burchfiel Anoop Shankar Serum Cotinine Levels and Prehypertension in Never Smokers International Journal of Hypertension |
| title | Serum Cotinine Levels and Prehypertension in Never Smokers |
| title_full | Serum Cotinine Levels and Prehypertension in Never Smokers |
| title_fullStr | Serum Cotinine Levels and Prehypertension in Never Smokers |
| title_full_unstemmed | Serum Cotinine Levels and Prehypertension in Never Smokers |
| title_short | Serum Cotinine Levels and Prehypertension in Never Smokers |
| title_sort | serum cotinine levels and prehypertension in never smokers |
| url | http://dx.doi.org/10.1155/2013/284524 |
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