Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies

Multi-omic identification of perineurial hyperplasia and lipid-associated nerve macrophages in human polyneuropathies

Abstract Diseases affecting multiple peripheral nerves, termed polyneuropathies (PNPs), are common, mechanistically heterogeneous, and their causes are challenging to identify. Here, we integrated single-nucleus transcriptomics of peripheral nerves from 33 human PNP patients and four controls (365,7...

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Main Authors: Michael Heming, Anna-Lena Börsch, Jolien Wolbert, Christian Thomas, Anne K. Mausberg, Fabian Szepanowski, Bianca Eggert, I-Na Lu, Julia Tietz, Finja Dienhart, Maja Meschnark, Jan-Kolja Strecker, Michael Glatza, Carolina Thomas, Noemi Gmahl, Christine Dambietz, Michael Müther, Anne-Kathrin Uerschels, Kathy Keyvani, Jens Minnerup, Kathrin Doppler, Nurcan Üçeyler, Julieta Aprea, Andreas Dahl, Ruth Stassart, Robert Fledrich, Heinz Wiendl, Claudia Sommer, Mark Stettner, Gerd Meyer zu Hörste
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62964-8
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