Association of Adipocytokines and Vitamin D Status in Tuberculosis
Leptin and Adiponectin are considered principal indicators of tuberculosis (TB). They are critical parts of the pathophysiological processes to which treatment can be applied. Thus, this research aimed at finding out the role of Adipocytokines and 25-dihydroxy vitamin D in the aetiology of tubercul...
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| Format: | Article |
| Language: | English |
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Tikrit University
2023-10-01
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| Series: | Tikrit Journal of Pure Science |
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| Online Access: | https://tjpsj.org/index.php/tjps/article/view/492 |
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| author | Hazhar M. Balaky Akam Jasim Mustafa Parween Abdulsamad Ismail |
| author_facet | Hazhar M. Balaky Akam Jasim Mustafa Parween Abdulsamad Ismail |
| author_sort | Hazhar M. Balaky |
| collection | DOAJ |
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Leptin and Adiponectin are considered principal indicators of tuberculosis (TB). They are critical parts of the pathophysiological processes to which treatment can be applied. Thus, this research aimed at finding out the role of Adipocytokines and 25-dihydroxy vitamin D in the aetiology of tuberculosis. The research sample included (90) participants divided into (50) tuberculosis patients and (40) healthy subjects representing the control group who were age and sex-matched. Circulating levels of adipocytokines and 25- dihydroxy vitamin D were analysed by using ELISA techniques. Compared to the subjects of control group, tuberculosis subjects had significantly (P<0.0001) lower levels of serum leptin (5.84±1.83 pg/mL) and vitamin D (2.77±0.52 ng/mL). However, compared to their control counterparts, tuberculosis patients had significantly (P<0.0001) higher levels of adiponectin (16.30±1.23 ng/mL). The ROC curve analysis of Leptin, Adiponectin, and 25-dihydroxy vitamin D indicated a high diagnostic value in predicting the risk of tuberculosis. The present study findings revealed that elevated serum adiponectin with decreased serum leptin levels and hypovitaminosis D are strongly correlated with the pathogenesis and state of tuberculosis.
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| format | Article |
| id | doaj-art-731d95d121b045d892bdd917926e210e |
| institution | Kabale University |
| issn | 1813-1662 2415-1726 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Tikrit University |
| record_format | Article |
| series | Tikrit Journal of Pure Science |
| spelling | doaj-art-731d95d121b045d892bdd917926e210e2025-08-20T03:28:59ZengTikrit UniversityTikrit Journal of Pure Science1813-16622415-17262023-10-0128510.25130/tjps.v28i5.492Association of Adipocytokines and Vitamin D Status in TuberculosisHazhar M. Balaky0Akam Jasim Mustafa1Parween Abdulsamad Ismail2Mergasor Technical Institute, Erbil Polytechnic University, Kurdistan Region, IraqDepartment of Chemistry, Faculty of Science, Soran University,Kurdistan Region- IraqDepartment pf Chemistry, College of Education, Salahaddin University Erbil, Kurdistan Region-Iraq Leptin and Adiponectin are considered principal indicators of tuberculosis (TB). They are critical parts of the pathophysiological processes to which treatment can be applied. Thus, this research aimed at finding out the role of Adipocytokines and 25-dihydroxy vitamin D in the aetiology of tuberculosis. The research sample included (90) participants divided into (50) tuberculosis patients and (40) healthy subjects representing the control group who were age and sex-matched. Circulating levels of adipocytokines and 25- dihydroxy vitamin D were analysed by using ELISA techniques. Compared to the subjects of control group, tuberculosis subjects had significantly (P<0.0001) lower levels of serum leptin (5.84±1.83 pg/mL) and vitamin D (2.77±0.52 ng/mL). However, compared to their control counterparts, tuberculosis patients had significantly (P<0.0001) higher levels of adiponectin (16.30±1.23 ng/mL). The ROC curve analysis of Leptin, Adiponectin, and 25-dihydroxy vitamin D indicated a high diagnostic value in predicting the risk of tuberculosis. The present study findings revealed that elevated serum adiponectin with decreased serum leptin levels and hypovitaminosis D are strongly correlated with the pathogenesis and state of tuberculosis. https://tjpsj.org/index.php/tjps/article/view/492LeptinAdiponectinVitamin DTuberculosisAdipocytokines |
| spellingShingle | Hazhar M. Balaky Akam Jasim Mustafa Parween Abdulsamad Ismail Association of Adipocytokines and Vitamin D Status in Tuberculosis Tikrit Journal of Pure Science Leptin Adiponectin Vitamin D Tuberculosis Adipocytokines |
| title | Association of Adipocytokines and Vitamin D Status in Tuberculosis |
| title_full | Association of Adipocytokines and Vitamin D Status in Tuberculosis |
| title_fullStr | Association of Adipocytokines and Vitamin D Status in Tuberculosis |
| title_full_unstemmed | Association of Adipocytokines and Vitamin D Status in Tuberculosis |
| title_short | Association of Adipocytokines and Vitamin D Status in Tuberculosis |
| title_sort | association of adipocytokines and vitamin d status in tuberculosis |
| topic | Leptin Adiponectin Vitamin D Tuberculosis Adipocytokines |
| url | https://tjpsj.org/index.php/tjps/article/view/492 |
| work_keys_str_mv | AT hazharmbalaky associationofadipocytokinesandvitamindstatusintuberculosis AT akamjasimmustafa associationofadipocytokinesandvitamindstatusintuberculosis AT parweenabdulsamadismail associationofadipocytokinesandvitamindstatusintuberculosis |