The Effects of Aerobic Exercises on Memory, Cerebral Edema, and Extracellular Neuronal Discharge in an Experimental Model of Traumatic Brain Injury: The Role of BDNF Expression
Background: Traumatic brain injury (TBI) remains a primary cause of mortality and is a significant contributor to various impairments, including somatosensory and cognitive deficits. The prevention and management of injuries require regular daily exercise. In this research, we examined the impact of...
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Kerman University of Medical Sciences
2024-08-01
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| author | Zahra Bazdidi Mohammad Ali Mirshekar Abbas Salehikia |
| author_facet | Zahra Bazdidi Mohammad Ali Mirshekar Abbas Salehikia |
| author_sort | Zahra Bazdidi |
| collection | DOAJ |
| description | Background: Traumatic brain injury (TBI) remains a primary cause of mortality and is a significant contributor to various impairments, including somatosensory and cognitive deficits. The prevention and management of injuries require regular daily exercise. In this research, we examined the impact of eight weeks of aerobic exercise on neurological outcomes, brain water content (BWC), blood-brain barrier (BBB) permeability, electrophysiological characteristics, and concentrations of brain-derived neurotrophic factor (BDNF) in an experimental model of TBI.Methods: Sixty-four male Wistar rats were divided into four groups: Control, Training, TBI, and Training-TBI. TBI was induced using the Marmarou method. After TBI induction, eight weeks of aerobic exercise were performed using a five-line animal treadmill. Then, the rats’ memory and learning were assessed using the Morris water maze. Electrodes were implanted in the skulls of anesthetized rats for single-unit recording. Neurological scores, BWC, BBB permeability, and cerebral tissue BDNF concentrations were measured 48 hours after exercise. Statistical analysis was conducted using one-way ANOVA, followed by Tukey’s post hoc test for multiple comparisons. P values < 0.05 were considered statistically significant.Results: Aerobic exercise significantly reversed the decrement of neurological scores, the neuronal firing rate of the hippocampus, increments of BWC, cognition deficits, and cerebral tissue Evans blue concentration after TBI compared with control. It also increased cerebral tissue BDNF, which had significantly decreased in TBI.Conclusion: Our results suggest that through BDNF increment, aerobic exercise exerts neuroprotective effects on memory impairment and the decrement of neuronal firing rate caused by TBI. |
| format | Article |
| id | doaj-art-731baa65e33b4b2cb31e812f22959eef |
| institution | DOAJ |
| issn | 1023-9510 2008-2843 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Kerman University of Medical Sciences |
| spelling | doaj-art-731baa65e33b4b2cb31e812f22959eef2025-08-20T02:57:45ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95102008-28432024-08-0131416517310.34172/jkmu.2024.2792358The Effects of Aerobic Exercises on Memory, Cerebral Edema, and Extracellular Neuronal Discharge in an Experimental Model of Traumatic Brain Injury: The Role of BDNF ExpressionZahra Bazdidi0Mohammad Ali Mirshekar1Abbas Salehikia2Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, IranClinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, IranDepartment of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, IranBackground: Traumatic brain injury (TBI) remains a primary cause of mortality and is a significant contributor to various impairments, including somatosensory and cognitive deficits. The prevention and management of injuries require regular daily exercise. In this research, we examined the impact of eight weeks of aerobic exercise on neurological outcomes, brain water content (BWC), blood-brain barrier (BBB) permeability, electrophysiological characteristics, and concentrations of brain-derived neurotrophic factor (BDNF) in an experimental model of TBI.Methods: Sixty-four male Wistar rats were divided into four groups: Control, Training, TBI, and Training-TBI. TBI was induced using the Marmarou method. After TBI induction, eight weeks of aerobic exercise were performed using a five-line animal treadmill. Then, the rats’ memory and learning were assessed using the Morris water maze. Electrodes were implanted in the skulls of anesthetized rats for single-unit recording. Neurological scores, BWC, BBB permeability, and cerebral tissue BDNF concentrations were measured 48 hours after exercise. Statistical analysis was conducted using one-way ANOVA, followed by Tukey’s post hoc test for multiple comparisons. P values < 0.05 were considered statistically significant.Results: Aerobic exercise significantly reversed the decrement of neurological scores, the neuronal firing rate of the hippocampus, increments of BWC, cognition deficits, and cerebral tissue Evans blue concentration after TBI compared with control. It also increased cerebral tissue BDNF, which had significantly decreased in TBI.Conclusion: Our results suggest that through BDNF increment, aerobic exercise exerts neuroprotective effects on memory impairment and the decrement of neuronal firing rate caused by TBI.https://jkmu.kmu.ac.ir/article_92358_e8cce3faa2f3535e3ac543b6bb700004.pdftraumatic brain injuryaerobic exerciseedemabdnfrat |
| spellingShingle | Zahra Bazdidi Mohammad Ali Mirshekar Abbas Salehikia The Effects of Aerobic Exercises on Memory, Cerebral Edema, and Extracellular Neuronal Discharge in an Experimental Model of Traumatic Brain Injury: The Role of BDNF Expression Journal of Kerman University of Medical Sciences traumatic brain injury aerobic exercise edema bdnf rat |
| title | The Effects of Aerobic Exercises on Memory, Cerebral Edema, and Extracellular Neuronal Discharge in an Experimental Model of Traumatic Brain Injury: The Role of BDNF Expression |
| title_full | The Effects of Aerobic Exercises on Memory, Cerebral Edema, and Extracellular Neuronal Discharge in an Experimental Model of Traumatic Brain Injury: The Role of BDNF Expression |
| title_fullStr | The Effects of Aerobic Exercises on Memory, Cerebral Edema, and Extracellular Neuronal Discharge in an Experimental Model of Traumatic Brain Injury: The Role of BDNF Expression |
| title_full_unstemmed | The Effects of Aerobic Exercises on Memory, Cerebral Edema, and Extracellular Neuronal Discharge in an Experimental Model of Traumatic Brain Injury: The Role of BDNF Expression |
| title_short | The Effects of Aerobic Exercises on Memory, Cerebral Edema, and Extracellular Neuronal Discharge in an Experimental Model of Traumatic Brain Injury: The Role of BDNF Expression |
| title_sort | effects of aerobic exercises on memory cerebral edema and extracellular neuronal discharge in an experimental model of traumatic brain injury the role of bdnf expression |
| topic | traumatic brain injury aerobic exercise edema bdnf rat |
| url | https://jkmu.kmu.ac.ir/article_92358_e8cce3faa2f3535e3ac543b6bb700004.pdf |
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