WAC Facilitates Mitophagy‐mediated MSC Osteogenesis and New Bone Formation via Protecting PINK1 from Ubiquitination‐Dependent Degradation

WAC Facilitates Mitophagy‐mediated MSC Osteogenesis and New Bone Formation via Protecting PINK1 from Ubiquitination‐Dependent Degradation

Abstract Osteogenic differentiation of mesenchymal stem cells (MSCs) plays a pivotal role in the pathogenesis and treatment of bone‐related conditions such as osteoporosis and bone regeneration. While the WW domain‐containing coiled‐coil adaptor (WAC) protein is primarily associated with transcripti...

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Main Authors: Shuai Fan, Jinteng Li, Guan Zheng, Ziyue Ma, Xiaoshuai Peng, Zhongyu Xie, Wenjie Liu, Wenhui Yu, Jiajie Lin, Zepeng Su, Peitao Xu, Peng Wang, Yanfeng Wu, Huiyong Shen, Guiwen Ye
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
mesenchymal stem cell
mitophagy
osteogenesis
PINK1
WAC
Online Access:https://doi.org/10.1002/advs.202404107
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