Present and Future in the Treatment of Diabetic Kidney Disease
Diabetic kidney disease is the leading cause of end-stage renal disease. Albuminuria is recognized as the most important prognostic factor for chronic kidney disease progression. For this reason, blockade of renin-angiotensin system remains the main recommended strategy, with either angiotensin conv...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/801348 |
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| _version_ | 1850222651388198912 |
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| author | Borja Quiroga David Arroyo Gabriel de Arriba |
| author_facet | Borja Quiroga David Arroyo Gabriel de Arriba |
| author_sort | Borja Quiroga |
| collection | DOAJ |
| description | Diabetic kidney disease is the leading cause of end-stage renal disease. Albuminuria is recognized as the most important prognostic factor for chronic kidney disease progression. For this reason, blockade of renin-angiotensin system remains the main recommended strategy, with either angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. However, other antiproteinuric treatments have begun to be studied, such as direct renin inhibitors or aldosterone blockers. Beyond antiproteinuric treatments, other drugs such as pentoxifylline or bardoxolone have yielded conflicting results. Finally, alternative pathogenic pathways are being explored, and emerging therapies including antifibrotic agents, endothelin receptor antagonists, or transcription factors show promising results. The aim of this review is to explain the advances in newer agents to treat diabetic kidney disease, along with the background of the renin-angiotensin system blockade. |
| format | Article |
| id | doaj-art-73192e55c95f4d029a2f1ae26b34f69e |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-73192e55c95f4d029a2f1ae26b34f69e2025-08-20T02:06:16ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/801348801348Present and Future in the Treatment of Diabetic Kidney DiseaseBorja Quiroga0David Arroyo1Gabriel de Arriba2Nephrology Unit, Hospital Universitario de Guadalajara, SpainNephrology Unit, Hospital Universitari Arnau de Vilanova, Lleida, SpainNephrology Unit, Hospital Universitario de Guadalajara, SpainDiabetic kidney disease is the leading cause of end-stage renal disease. Albuminuria is recognized as the most important prognostic factor for chronic kidney disease progression. For this reason, blockade of renin-angiotensin system remains the main recommended strategy, with either angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. However, other antiproteinuric treatments have begun to be studied, such as direct renin inhibitors or aldosterone blockers. Beyond antiproteinuric treatments, other drugs such as pentoxifylline or bardoxolone have yielded conflicting results. Finally, alternative pathogenic pathways are being explored, and emerging therapies including antifibrotic agents, endothelin receptor antagonists, or transcription factors show promising results. The aim of this review is to explain the advances in newer agents to treat diabetic kidney disease, along with the background of the renin-angiotensin system blockade.http://dx.doi.org/10.1155/2015/801348 |
| spellingShingle | Borja Quiroga David Arroyo Gabriel de Arriba Present and Future in the Treatment of Diabetic Kidney Disease Journal of Diabetes Research |
| title | Present and Future in the Treatment of Diabetic Kidney Disease |
| title_full | Present and Future in the Treatment of Diabetic Kidney Disease |
| title_fullStr | Present and Future in the Treatment of Diabetic Kidney Disease |
| title_full_unstemmed | Present and Future in the Treatment of Diabetic Kidney Disease |
| title_short | Present and Future in the Treatment of Diabetic Kidney Disease |
| title_sort | present and future in the treatment of diabetic kidney disease |
| url | http://dx.doi.org/10.1155/2015/801348 |
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