Kidney damage associated with COVID-19: from the acute to the chronic phase
Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) infection is well established as a systemic disease including kidney damage. The entry point into the renal cell remains the angiotensin-converting enzyme 2 (ACE-2) receptor and the spectrum of renal lesions is broad, with a clear predomin...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2316885 |
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| author | Yannick Mayamba Nlandu Elliot Koranteng Tannor Titilope Adetoun Bamikefa Jean-Robert Rissassi Makulo |
| author_facet | Yannick Mayamba Nlandu Elliot Koranteng Tannor Titilope Adetoun Bamikefa Jean-Robert Rissassi Makulo |
| author_sort | Yannick Mayamba Nlandu |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) infection is well established as a systemic disease including kidney damage. The entry point into the renal cell remains the angiotensin-converting enzyme 2 (ACE-2) receptor and the spectrum of renal lesions is broad, with a clear predominance of structural and functional tubular lesions. The most common form of glomerular injury is collapsing glomerulopathy (CG), which is strongly associated with apolipoprotein L1(APOL-1) risk variants. These acute lesions, which are secondary to the direct or indirect effects of SARS-CoV-2, can progress to chronicity and are specific to long COVID-19 in the absence of any other cause. Residual inflammation associated with SARS-CoV-2 infection, in addition to acute kidney injury (AKI) as a transitional state with or without severe histological lesions, may be responsible for greater kidney function decline in mild-to-moderate COVID-19. This review discusses the evidence for renal histological markers of chronicity in COVID-19 patients and triggers of low-grade inflammation that may explain the decline in kidney function in the post-COVID-19 period. |
| format | Article |
| id | doaj-art-7317081d72f04341b2e06e544242a655 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-7317081d72f04341b2e06e544242a6552025-01-23T04:17:48ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2316885Kidney damage associated with COVID-19: from the acute to the chronic phaseYannick Mayamba Nlandu0Elliot Koranteng Tannor1Titilope Adetoun Bamikefa2Jean-Robert Rissassi Makulo3Nephrology Unit, Kinshasa University Hospital, Kinshasa, Democratic Republic of the CongoDepartment of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaRenal Unit, Uniosun Teaching Hospital Osogbo, Osun State University, Osogbo, Osun State, NigeriaNephrology Unit, Kinshasa University Hospital, Kinshasa, Democratic Republic of the CongoSevere acute respiratory syndrome coronavirus-2 (SARS-COV-2) infection is well established as a systemic disease including kidney damage. The entry point into the renal cell remains the angiotensin-converting enzyme 2 (ACE-2) receptor and the spectrum of renal lesions is broad, with a clear predominance of structural and functional tubular lesions. The most common form of glomerular injury is collapsing glomerulopathy (CG), which is strongly associated with apolipoprotein L1(APOL-1) risk variants. These acute lesions, which are secondary to the direct or indirect effects of SARS-CoV-2, can progress to chronicity and are specific to long COVID-19 in the absence of any other cause. Residual inflammation associated with SARS-CoV-2 infection, in addition to acute kidney injury (AKI) as a transitional state with or without severe histological lesions, may be responsible for greater kidney function decline in mild-to-moderate COVID-19. This review discusses the evidence for renal histological markers of chronicity in COVID-19 patients and triggers of low-grade inflammation that may explain the decline in kidney function in the post-COVID-19 period.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2316885Kidney damageCOVID-19chronic kidney diseaseacute kidney injurySARS-CoV-2 |
| spellingShingle | Yannick Mayamba Nlandu Elliot Koranteng Tannor Titilope Adetoun Bamikefa Jean-Robert Rissassi Makulo Kidney damage associated with COVID-19: from the acute to the chronic phase Renal Failure Kidney damage COVID-19 chronic kidney disease acute kidney injury SARS-CoV-2 |
| title | Kidney damage associated with COVID-19: from the acute to the chronic phase |
| title_full | Kidney damage associated with COVID-19: from the acute to the chronic phase |
| title_fullStr | Kidney damage associated with COVID-19: from the acute to the chronic phase |
| title_full_unstemmed | Kidney damage associated with COVID-19: from the acute to the chronic phase |
| title_short | Kidney damage associated with COVID-19: from the acute to the chronic phase |
| title_sort | kidney damage associated with covid 19 from the acute to the chronic phase |
| topic | Kidney damage COVID-19 chronic kidney disease acute kidney injury SARS-CoV-2 |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2316885 |
| work_keys_str_mv | AT yannickmayambanlandu kidneydamageassociatedwithcovid19fromtheacutetothechronicphase AT elliotkorantengtannor kidneydamageassociatedwithcovid19fromtheacutetothechronicphase AT titilopeadetounbamikefa kidneydamageassociatedwithcovid19fromtheacutetothechronicphase AT jeanrobertrissassimakulo kidneydamageassociatedwithcovid19fromtheacutetothechronicphase |