An Interesting Case of Isolated False-Reactive Hepatitis B Surface Antigen
The standard serologic markers used to diagnose hepatitis B infection include hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), total hepatitis B core antibody (anti-HBc), and IgM antibody to hepatitis B core antigen (IgM anti-HBc). Different markers or combinations of ma...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2021/9928098 |
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| author | Victoria Costa Zhen Zhao Sabrina E. Racine-Brzostek Gadi Lalazar He S. Yang |
| author_facet | Victoria Costa Zhen Zhao Sabrina E. Racine-Brzostek Gadi Lalazar He S. Yang |
| author_sort | Victoria Costa |
| collection | DOAJ |
| description | The standard serologic markers used to diagnose hepatitis B infection include hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), total hepatitis B core antibody (anti-HBc), and IgM antibody to hepatitis B core antigen (IgM anti-HBc). Different markers or combinations of markers are used to identify different phases of HBV infection and determine whether a patient has acute or chronic infection or immunity due to prior infection or vaccination or is seronegative and susceptible to future infection. Isolated HBsAg seropositivity is a peculiar serological pattern that requires investigation. Herein, we present a case of an asymptomatic female without a history of liver disease or evident risk factors for hepatitis, who underwent screening for infectious disease prior to resection of basal cell carcinoma involving her eyelid. The patient’s laboratory testing showed positivity for HBsAg and the HIV 1/2 screen. To investigate, we performed serial dilutions, utilized heterophilicantibody blocking tubes, and repeated analysis using a different commercial assay (Abbott Architect i2000), all in support of a false-positive result attributed to a heterophilic antibody. Hence, we demonstrate that heterophilic antibody interference can result in isolated HBsAg positivity and recommend considering this form of interference in the differential where there is low clinical suspicion for viral infection. |
| format | Article |
| id | doaj-art-7313ca49a00a447b97cc662a94aaeeae |
| institution | Kabale University |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-7313ca49a00a447b97cc662a94aaeeae2025-08-20T03:33:50ZengWileyCase Reports in Hepatology2090-65872090-65952021-01-01202110.1155/2021/99280989928098An Interesting Case of Isolated False-Reactive Hepatitis B Surface AntigenVictoria Costa0Zhen Zhao1Sabrina E. Racine-Brzostek2Gadi Lalazar3He S. Yang4Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USADepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USADepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USADepartment of Gastroenterology and Hepatology, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USADepartment of Pathology and Laboratory Medicine, New York Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USAThe standard serologic markers used to diagnose hepatitis B infection include hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), total hepatitis B core antibody (anti-HBc), and IgM antibody to hepatitis B core antigen (IgM anti-HBc). Different markers or combinations of markers are used to identify different phases of HBV infection and determine whether a patient has acute or chronic infection or immunity due to prior infection or vaccination or is seronegative and susceptible to future infection. Isolated HBsAg seropositivity is a peculiar serological pattern that requires investigation. Herein, we present a case of an asymptomatic female without a history of liver disease or evident risk factors for hepatitis, who underwent screening for infectious disease prior to resection of basal cell carcinoma involving her eyelid. The patient’s laboratory testing showed positivity for HBsAg and the HIV 1/2 screen. To investigate, we performed serial dilutions, utilized heterophilicantibody blocking tubes, and repeated analysis using a different commercial assay (Abbott Architect i2000), all in support of a false-positive result attributed to a heterophilic antibody. Hence, we demonstrate that heterophilic antibody interference can result in isolated HBsAg positivity and recommend considering this form of interference in the differential where there is low clinical suspicion for viral infection.http://dx.doi.org/10.1155/2021/9928098 |
| spellingShingle | Victoria Costa Zhen Zhao Sabrina E. Racine-Brzostek Gadi Lalazar He S. Yang An Interesting Case of Isolated False-Reactive Hepatitis B Surface Antigen Case Reports in Hepatology |
| title | An Interesting Case of Isolated False-Reactive Hepatitis B Surface Antigen |
| title_full | An Interesting Case of Isolated False-Reactive Hepatitis B Surface Antigen |
| title_fullStr | An Interesting Case of Isolated False-Reactive Hepatitis B Surface Antigen |
| title_full_unstemmed | An Interesting Case of Isolated False-Reactive Hepatitis B Surface Antigen |
| title_short | An Interesting Case of Isolated False-Reactive Hepatitis B Surface Antigen |
| title_sort | interesting case of isolated false reactive hepatitis b surface antigen |
| url | http://dx.doi.org/10.1155/2021/9928098 |
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