Silver Nanoparticles Based on Annona muricata Peel Reduce Cell Viability in Medulloblastoma and Neuroblastoma Cell Lines
Silver nanoparticles (AgNPs) can be obtained from plants and other organisms through green synthesis methods, considered eco-friendly and highly biocompatible. In this way, using plants with antitumor bioactive compounds increases cytotoxicity against tumor cells, acting in synergy between plant bio...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Journal of Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/2024/2263514 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849414489056739328 |
|---|---|
| author | Eduardo Lira-Díaz Ricardo Cruz-Márquez María Guadalupe González-Pedroza Oscar Gonzalez-Perez Raúl Alberto Morales-Luckie Juan José Acevedo-Fernández |
| author_facet | Eduardo Lira-Díaz Ricardo Cruz-Márquez María Guadalupe González-Pedroza Oscar Gonzalez-Perez Raúl Alberto Morales-Luckie Juan José Acevedo-Fernández |
| author_sort | Eduardo Lira-Díaz |
| collection | DOAJ |
| description | Silver nanoparticles (AgNPs) can be obtained from plants and other organisms through green synthesis methods, considered eco-friendly and highly biocompatible. In this way, using plants with antitumor bioactive compounds increases cytotoxicity against tumor cells, acting in synergy between plant bioactive compounds (covering the nanoparticle) and AgNPs by itself. Acetogenins are the signature bioactive compounds present in Annona muricata (soursop) that induce tumor cell death by blocking respiratory complex 1 of the electron transport chain of the mitochondria, which is overexpressed in high-grade tumors such as medulloblastoma, a high-grade tumor of embryonic origin that affects the pediatric population. In this study, we evaluated the effects of AgNPs derived from an aqueous extract of soursop peel on neuroblastoma (CHP-212) and medulloblastoma (Daoy and D341 Med) cell lines. Additionally, we evaluated the viability of fibroblasts (HDFn) and macrophages (RAW 264.7) to observe biosafety in nontumor cells. Our results showed that AgNPs in soursop peel reduced the viability of CHP-212, Daoy, and D341 Med cell lines, in contrast to the fibroblast cell line. Thus, AgNPs derived from the aqueous extract of soursop peel may serve as a promising therapeutic tool for treating brain tumors. |
| format | Article |
| id | doaj-art-731387978bb74e9696a887e536aa2ecf |
| institution | Kabale University |
| issn | 1687-9511 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nanotechnology |
| spelling | doaj-art-731387978bb74e9696a887e536aa2ecf2025-08-20T03:33:50ZengWileyJournal of Nanotechnology1687-95112024-01-01202410.1155/2024/2263514Silver Nanoparticles Based on Annona muricata Peel Reduce Cell Viability in Medulloblastoma and Neuroblastoma Cell LinesEduardo Lira-Díaz0Ricardo Cruz-Márquez1María Guadalupe González-Pedroza2Oscar Gonzalez-Perez3Raúl Alberto Morales-Luckie4Juan José Acevedo-Fernández5Laboratorio de NanomaterialesDepartamento de BiotecnologíaDepartamento de BiotecnologíaLaboratorio de NeurocienciasLaboratorio de NanomaterialesLaboratorio de Biología de Células TroncalesSilver nanoparticles (AgNPs) can be obtained from plants and other organisms through green synthesis methods, considered eco-friendly and highly biocompatible. In this way, using plants with antitumor bioactive compounds increases cytotoxicity against tumor cells, acting in synergy between plant bioactive compounds (covering the nanoparticle) and AgNPs by itself. Acetogenins are the signature bioactive compounds present in Annona muricata (soursop) that induce tumor cell death by blocking respiratory complex 1 of the electron transport chain of the mitochondria, which is overexpressed in high-grade tumors such as medulloblastoma, a high-grade tumor of embryonic origin that affects the pediatric population. In this study, we evaluated the effects of AgNPs derived from an aqueous extract of soursop peel on neuroblastoma (CHP-212) and medulloblastoma (Daoy and D341 Med) cell lines. Additionally, we evaluated the viability of fibroblasts (HDFn) and macrophages (RAW 264.7) to observe biosafety in nontumor cells. Our results showed that AgNPs in soursop peel reduced the viability of CHP-212, Daoy, and D341 Med cell lines, in contrast to the fibroblast cell line. Thus, AgNPs derived from the aqueous extract of soursop peel may serve as a promising therapeutic tool for treating brain tumors.http://dx.doi.org/10.1155/2024/2263514 |
| spellingShingle | Eduardo Lira-Díaz Ricardo Cruz-Márquez María Guadalupe González-Pedroza Oscar Gonzalez-Perez Raúl Alberto Morales-Luckie Juan José Acevedo-Fernández Silver Nanoparticles Based on Annona muricata Peel Reduce Cell Viability in Medulloblastoma and Neuroblastoma Cell Lines Journal of Nanotechnology |
| title | Silver Nanoparticles Based on Annona muricata Peel Reduce Cell Viability in Medulloblastoma and Neuroblastoma Cell Lines |
| title_full | Silver Nanoparticles Based on Annona muricata Peel Reduce Cell Viability in Medulloblastoma and Neuroblastoma Cell Lines |
| title_fullStr | Silver Nanoparticles Based on Annona muricata Peel Reduce Cell Viability in Medulloblastoma and Neuroblastoma Cell Lines |
| title_full_unstemmed | Silver Nanoparticles Based on Annona muricata Peel Reduce Cell Viability in Medulloblastoma and Neuroblastoma Cell Lines |
| title_short | Silver Nanoparticles Based on Annona muricata Peel Reduce Cell Viability in Medulloblastoma and Neuroblastoma Cell Lines |
| title_sort | silver nanoparticles based on annona muricata peel reduce cell viability in medulloblastoma and neuroblastoma cell lines |
| url | http://dx.doi.org/10.1155/2024/2263514 |
| work_keys_str_mv | AT eduardoliradiaz silvernanoparticlesbasedonannonamuricatapeelreducecellviabilityinmedulloblastomaandneuroblastomacelllines AT ricardocruzmarquez silvernanoparticlesbasedonannonamuricatapeelreducecellviabilityinmedulloblastomaandneuroblastomacelllines AT mariaguadalupegonzalezpedroza silvernanoparticlesbasedonannonamuricatapeelreducecellviabilityinmedulloblastomaandneuroblastomacelllines AT oscargonzalezperez silvernanoparticlesbasedonannonamuricatapeelreducecellviabilityinmedulloblastomaandneuroblastomacelllines AT raulalbertomoralesluckie silvernanoparticlesbasedonannonamuricatapeelreducecellviabilityinmedulloblastomaandneuroblastomacelllines AT juanjoseacevedofernandez silvernanoparticlesbasedonannonamuricatapeelreducecellviabilityinmedulloblastomaandneuroblastomacelllines |