Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast Cancer
Inhibition of triple-negative breast cancer metastasis has long been a challenge, mainly due to the difficulty in identifying factors that contribute to this process. In this study, freshly isolated triple-negative breast cancer biopsied cells obtained from consenting patients were subjected to flow...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/5412007 |
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| _version_ | 1832550425089277952 |
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| author | Yanfei Ma Yanghong Li Pengwei Guo Jingjie Zhao Qiang Qin Jiajia Wang Zhengfang Liang Dalong Wei Zechen Wang Jiajia Shen Siyuan He Qianli Tang Guanming Lu Guiling Shi Lingzhang Meng |
| author_facet | Yanfei Ma Yanghong Li Pengwei Guo Jingjie Zhao Qiang Qin Jiajia Wang Zhengfang Liang Dalong Wei Zechen Wang Jiajia Shen Siyuan He Qianli Tang Guanming Lu Guiling Shi Lingzhang Meng |
| author_sort | Yanfei Ma |
| collection | DOAJ |
| description | Inhibition of triple-negative breast cancer metastasis has long been a challenge, mainly due to the difficulty in identifying factors that contribute to this process. In this study, freshly isolated triple-negative breast cancer biopsied cells obtained from consenting patients were subjected to flow cytometry and bioinformatic analysis to identify three endothelial cell subclusters: EC (ATP1B3), EC (HSPA1B), and EC (KRT7) in the tumor microenvironment. These endothelial cell subclusters exhibited distinguishing biological features. Based on differentially expressed genes derived from the subclusters, gene set enrichment analysis showed that EC (ATP1B3) and EC (HSPA1B) contribute to the process of metastasis, for example, in fibrosarcoma and anaplastic carcinoma. In this study, we identified the heterogeneity of endothelial cells in the human breast cancer and have provided insights into its role in metastasis. |
| format | Article |
| id | doaj-art-73120cb3cfd24e62aab05205a621e679 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-73120cb3cfd24e62aab05205a621e6792025-02-03T06:06:53ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/5412007Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast CancerYanfei Ma0Yanghong Li1Pengwei Guo2Jingjie Zhao3Qiang Qin4Jiajia Wang5Zhengfang Liang6Dalong Wei7Zechen Wang8Jiajia Shen9Siyuan He10Qianli Tang11Guanming Lu12Guiling Shi13Lingzhang Meng14Jinan UniversityCenter for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Life Science and Clinical Research CenterDepartment of Gland SurgeryCenter for Systemic Inflammation Research (CSIR)Department of Urinary SurgeryDepartment of Urinary SurgeryCenter for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Jinan UniversityCenter for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Center for Systemic Inflammation Research (CSIR)Inhibition of triple-negative breast cancer metastasis has long been a challenge, mainly due to the difficulty in identifying factors that contribute to this process. In this study, freshly isolated triple-negative breast cancer biopsied cells obtained from consenting patients were subjected to flow cytometry and bioinformatic analysis to identify three endothelial cell subclusters: EC (ATP1B3), EC (HSPA1B), and EC (KRT7) in the tumor microenvironment. These endothelial cell subclusters exhibited distinguishing biological features. Based on differentially expressed genes derived from the subclusters, gene set enrichment analysis showed that EC (ATP1B3) and EC (HSPA1B) contribute to the process of metastasis, for example, in fibrosarcoma and anaplastic carcinoma. In this study, we identified the heterogeneity of endothelial cells in the human breast cancer and have provided insights into its role in metastasis.http://dx.doi.org/10.1155/2022/5412007 |
| spellingShingle | Yanfei Ma Yanghong Li Pengwei Guo Jingjie Zhao Qiang Qin Jiajia Wang Zhengfang Liang Dalong Wei Zechen Wang Jiajia Shen Siyuan He Qianli Tang Guanming Lu Guiling Shi Lingzhang Meng Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast Cancer Journal of Immunology Research |
| title | Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast Cancer |
| title_full | Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast Cancer |
| title_fullStr | Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast Cancer |
| title_full_unstemmed | Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast Cancer |
| title_short | Endothelial Cells Potentially Participate in the Metastasis of Triple-Negative Breast Cancer |
| title_sort | endothelial cells potentially participate in the metastasis of triple negative breast cancer |
| url | http://dx.doi.org/10.1155/2022/5412007 |
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