Study protocol for a randomized clinical trial evaluating the safety and efficacy of autologous adipose-derived stem cell therapy for ulcers in patients with critical limb ischemia.

Study protocol for a randomized clinical trial evaluating the safety and efficacy of autologous adipose-derived stem cell therapy for ulcers in patients with critical limb ischemia.

<h4>Background</h4>Peripheral artery disease (PAD) can develop into critical limb ischemia (CLI), which is characterized by resting pain at rest, ulcerations, or gangrene, with a high risk of amputation. The optimum course of treatment at this point is arterial revascularization, althoug...

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Main Authors: Francisco José de Oliveira Filho, Lenize da Silva Rodrigues, Sidia Maria Baptista do Amaral, Pedro Luciano Mellucci Filho, Natália Bronzatto Medolago, Ana Lívia de Carvalho Bovolato, Rita de Cássia Alvarado, Matheus Bertanha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0318922
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