Prevalence and associated risk factors of post COVID fatigue among Parkinson’s disease patients during one year follow up
Abstract One of the most common post-COVID-19 condition is persistent fatigue, while post-COVID fatigue among Parkinson’s disease (PD) patients is less known. This study was aimed to investigate the prevalence and risk factors of post-COVID fatigue in PD patients at 1 month and 12 months after sympt...
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-83567-1 |
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| author | Chenlu Yang Dandan Guo Yugang Zhu Min Tian Bohan Zhang Yang Yang Qingchao Yang Yiming Liu |
| author_facet | Chenlu Yang Dandan Guo Yugang Zhu Min Tian Bohan Zhang Yang Yang Qingchao Yang Yiming Liu |
| author_sort | Chenlu Yang |
| collection | DOAJ |
| description | Abstract One of the most common post-COVID-19 condition is persistent fatigue, while post-COVID fatigue among Parkinson’s disease (PD) patients is less known. This study was aimed to investigate the prevalence and risk factors of post-COVID fatigue in PD patients at 1 month and 12 months after symptom onset. PD patients attending clinic from December 2022 to January 2023 were enrolled consecutively in the study. All participants were assessed demographics, details of COVID-19 infection, clinical characteristics as well as fatigue status with Fatigue Severity Scale (FSS) (cutoff ≥ 36) at 1-month and 12-month after symptom onset. Univariate and multivariate Logistic regression analysis were used to evaluate the risk factors of post-COVID fatigue. Fatigue symptoms were reported by 75.89% of PD patients and associated with decreased physical activity and number of initial symptoms of COVID-19 at 1 month. Meanwhile, 32.99% of PD patients at 12 months reported persistent fatigue. Using of antiviral drugs, decreased physical activity, anxiety status and delayed ON were associated with persistent fatigue at 12 months. Clinically persistent fatigue was pervasive in our study at 12-month after COVID infection. These findings implicate using of antiviral drugs, decreased physical activity, anxiety status and delayed ON were possible predictors of post-COVID persistent fatigue. |
| format | Article |
| id | doaj-art-73104a5906b74777a21f0bbeae2df4e9 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-73104a5906b74777a21f0bbeae2df4e92025-08-20T01:47:58ZengNature PortfolioScientific Reports2045-23222024-12-0114111110.1038/s41598-024-83567-1Prevalence and associated risk factors of post COVID fatigue among Parkinson’s disease patients during one year follow upChenlu Yang0Dandan Guo1Yugang Zhu2Min Tian3Bohan Zhang4Yang Yang5Qingchao Yang6Yiming Liu7Department of Neurology, Qilu Hospital of Shandong UniversityDepartment of Neurology, Qilu Hospital of Shandong UniversityDepartment of Neurology, Qilu Hospital of Shandong UniversityDepartment of Neurology, Qilu Hospital of Shandong UniversityDepartment of Neurology, Qilu Hospital of Shandong UniversityDepartment of Neurology, Qilu Hospital of Shandong UniversityDepartment of Neurology, Qilu Hospital of Shandong UniversityDepartment of Neurology, Qilu Hospital of Shandong UniversityAbstract One of the most common post-COVID-19 condition is persistent fatigue, while post-COVID fatigue among Parkinson’s disease (PD) patients is less known. This study was aimed to investigate the prevalence and risk factors of post-COVID fatigue in PD patients at 1 month and 12 months after symptom onset. PD patients attending clinic from December 2022 to January 2023 were enrolled consecutively in the study. All participants were assessed demographics, details of COVID-19 infection, clinical characteristics as well as fatigue status with Fatigue Severity Scale (FSS) (cutoff ≥ 36) at 1-month and 12-month after symptom onset. Univariate and multivariate Logistic regression analysis were used to evaluate the risk factors of post-COVID fatigue. Fatigue symptoms were reported by 75.89% of PD patients and associated with decreased physical activity and number of initial symptoms of COVID-19 at 1 month. Meanwhile, 32.99% of PD patients at 12 months reported persistent fatigue. Using of antiviral drugs, decreased physical activity, anxiety status and delayed ON were associated with persistent fatigue at 12 months. Clinically persistent fatigue was pervasive in our study at 12-month after COVID infection. These findings implicate using of antiviral drugs, decreased physical activity, anxiety status and delayed ON were possible predictors of post-COVID persistent fatigue.https://doi.org/10.1038/s41598-024-83567-1Post-COVID fatigueParkinson’s diseaseFatigueSARS-CoV-2 |
| spellingShingle | Chenlu Yang Dandan Guo Yugang Zhu Min Tian Bohan Zhang Yang Yang Qingchao Yang Yiming Liu Prevalence and associated risk factors of post COVID fatigue among Parkinson’s disease patients during one year follow up Scientific Reports Post-COVID fatigue Parkinson’s disease Fatigue SARS-CoV-2 |
| title | Prevalence and associated risk factors of post COVID fatigue among Parkinson’s disease patients during one year follow up |
| title_full | Prevalence and associated risk factors of post COVID fatigue among Parkinson’s disease patients during one year follow up |
| title_fullStr | Prevalence and associated risk factors of post COVID fatigue among Parkinson’s disease patients during one year follow up |
| title_full_unstemmed | Prevalence and associated risk factors of post COVID fatigue among Parkinson’s disease patients during one year follow up |
| title_short | Prevalence and associated risk factors of post COVID fatigue among Parkinson’s disease patients during one year follow up |
| title_sort | prevalence and associated risk factors of post covid fatigue among parkinson s disease patients during one year follow up |
| topic | Post-COVID fatigue Parkinson’s disease Fatigue SARS-CoV-2 |
| url | https://doi.org/10.1038/s41598-024-83567-1 |
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