Temporal prediction and feedforward control in cerebellar ataxia during spontaneous, instructed, and adaptive auditory-motor coupling while walking
Abstract Auditory-motor coupling, the entrainment of movement to an auditory stimulus, involves processes of temporal prediction and feedforward control. The cerebellum is central to these mechanisms, with deficits contributing to ataxia, characterized by incoordination and increased movement variab...
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Nature Portfolio
2025-08-01
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| Online Access: | https://doi.org/10.1038/s41598-025-12316-9 |
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| author | Lousin Moumdjian Bart Moens Mario Manto Pierre Cabaraux Bart Van Wijmeersch Daphne Kos Marc Leman Peter Feys |
| author_facet | Lousin Moumdjian Bart Moens Mario Manto Pierre Cabaraux Bart Van Wijmeersch Daphne Kos Marc Leman Peter Feys |
| author_sort | Lousin Moumdjian |
| collection | DOAJ |
| description | Abstract Auditory-motor coupling, the entrainment of movement to an auditory stimulus, involves processes of temporal prediction and feedforward control. The cerebellum is central to these mechanisms, with deficits contributing to ataxia, characterized by incoordination and increased movement variability. Previous research investigated these mechanisms through perceptual or paced finger-tapping tasks. However, little is known about how these processes interact in complex motor tasks, such as walking, which require feedforward control and voluntary adaptability. Thus, the dynamic interplay between temporal prediction and feedforward control in persons with cerebellar ataxia (PwCA) during walking was assessed in three auditory-motor coupling paradigms (spontaneous, instructed and adaptive), involving walking to music and metronomes at different frequencies. The adaptive paradigm additionally incorporated real-time alignment algorithms. Sixteen PwCA (scale for the assessment and rating of ataxia 3.59 ± 2.92) and fourteen healthy controls (HCs) participated. Overall, patients showed spared temporal predictions assessed by synchronization accuracy. Yet reduced synchronization consistency and gait modulation was observed in PwCA as compared to HCs, consistent with deficits of feedforward control. The adaptive alignment algorithm may have compensated for feedforward impairments, thereby promoting enhanced synchronization and gait dynamics. This approach warrants further investigation and holds potential for integration into rehabilitation strategies for persons with mild ataxia. |
| format | Article |
| id | doaj-art-731034d70b5242aeae5b1dfb9c7aceb4 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-731034d70b5242aeae5b1dfb9c7aceb42025-08-20T03:42:41ZengNature PortfolioScientific Reports2045-23222025-08-0115112110.1038/s41598-025-12316-9Temporal prediction and feedforward control in cerebellar ataxia during spontaneous, instructed, and adaptive auditory-motor coupling while walkingLousin Moumdjian0Bart Moens1Mario Manto2Pierre Cabaraux3Bart Van Wijmeersch4Daphne Kos5Marc Leman6Peter Feys7REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt UniversityIPEM Institute for Systematic Musicology, Ghent UniversityService de Neurologie, CHU-CharleroiNeurologieal rehabilitation ward, Department of neurology, Hôpital universitaire de Bruxelles, Université libre de BruxellesREVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt UniversityNational MS Center MelsbroekIPEM Institute for Systematic Musicology, Ghent UniversityREVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt UniversityAbstract Auditory-motor coupling, the entrainment of movement to an auditory stimulus, involves processes of temporal prediction and feedforward control. The cerebellum is central to these mechanisms, with deficits contributing to ataxia, characterized by incoordination and increased movement variability. Previous research investigated these mechanisms through perceptual or paced finger-tapping tasks. However, little is known about how these processes interact in complex motor tasks, such as walking, which require feedforward control and voluntary adaptability. Thus, the dynamic interplay between temporal prediction and feedforward control in persons with cerebellar ataxia (PwCA) during walking was assessed in three auditory-motor coupling paradigms (spontaneous, instructed and adaptive), involving walking to music and metronomes at different frequencies. The adaptive paradigm additionally incorporated real-time alignment algorithms. Sixteen PwCA (scale for the assessment and rating of ataxia 3.59 ± 2.92) and fourteen healthy controls (HCs) participated. Overall, patients showed spared temporal predictions assessed by synchronization accuracy. Yet reduced synchronization consistency and gait modulation was observed in PwCA as compared to HCs, consistent with deficits of feedforward control. The adaptive alignment algorithm may have compensated for feedforward impairments, thereby promoting enhanced synchronization and gait dynamics. This approach warrants further investigation and holds potential for integration into rehabilitation strategies for persons with mild ataxia.https://doi.org/10.1038/s41598-025-12316-9WalkingAuditorySynchronizationMusicMetronomesRehabilitation |
| spellingShingle | Lousin Moumdjian Bart Moens Mario Manto Pierre Cabaraux Bart Van Wijmeersch Daphne Kos Marc Leman Peter Feys Temporal prediction and feedforward control in cerebellar ataxia during spontaneous, instructed, and adaptive auditory-motor coupling while walking Scientific Reports Walking Auditory Synchronization Music Metronomes Rehabilitation |
| title | Temporal prediction and feedforward control in cerebellar ataxia during spontaneous, instructed, and adaptive auditory-motor coupling while walking |
| title_full | Temporal prediction and feedforward control in cerebellar ataxia during spontaneous, instructed, and adaptive auditory-motor coupling while walking |
| title_fullStr | Temporal prediction and feedforward control in cerebellar ataxia during spontaneous, instructed, and adaptive auditory-motor coupling while walking |
| title_full_unstemmed | Temporal prediction and feedforward control in cerebellar ataxia during spontaneous, instructed, and adaptive auditory-motor coupling while walking |
| title_short | Temporal prediction and feedforward control in cerebellar ataxia during spontaneous, instructed, and adaptive auditory-motor coupling while walking |
| title_sort | temporal prediction and feedforward control in cerebellar ataxia during spontaneous instructed and adaptive auditory motor coupling while walking |
| topic | Walking Auditory Synchronization Music Metronomes Rehabilitation |
| url | https://doi.org/10.1038/s41598-025-12316-9 |
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