Gastrointestinal tract colonization with Candida albicans and mucosal immune response in mice treated with Artemisinin and Fluconazole orally
Abstract The results showed that after treating <italic>C. albicans</italic> with Artemisinin (0.104 mg/ml) for 3 hours the number of <italic>C. albicans</italic> decreased and affected the morphology hyphae and growth of <italic>Candida</italic> compared with Flu...
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Academia Brasileira de Ciências
2025-07-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| author | SEENAA J. BADER ATYAF S. HAMIED |
| author_facet | SEENAA J. BADER ATYAF S. HAMIED |
| author_sort | SEENAA J. BADER |
| collection | DOAJ |
| description | Abstract The results showed that after treating <italic>C. albicans</italic> with Artemisinin (0.104 mg/ml) for 3 hours the number of <italic>C. albicans</italic> decreased and affected the morphology hyphae and growth of <italic>Candida</italic> compared with Fluconazole (150 mg/ml) and control (infected mice). The biomarker levels in the tongue showed high levels of MDA and TGFβ (623±1.5pg/ml, 586.1±0.13pg/ml respectively) in (infected mice with fungi). IL-37 was recorded high level (49.21±0.21pg/ml) in (Neoral +Fungi + artemisinin + fluconazole) compared with negative control. The finding biomarker levels in stomach showed high levels of MDA and IL-37 (533.8±1.9, 69.76±0.39pg/ml) in (Neoral + Fungi + artemisinin + fluconazole) compared with control. TGF β was recorded high level (1002±0.32pg/ml) in (Neoral + Fungi + Artemisinin) compared with negative control. The biomarker levels in intestine showed high levels of MDA and TGFβ (1149±0.34pg/ml, 1089±0.3pg/ml respectively) in (mice infected with fungi). IL-37 was recorded high level (74.14±0.14pg/ml) in (Neoral + Fungi + artemisinin + fluconazole) compared with negative control (normal mice). The biomarker levels in serum showed high levels of MDA and TGFβ (1668±0.12 pg/ml, 1629±0.05 pg/ml respectively) in (mice infected with fungi) at (P<0.05). IL-37 was recorded high level (135.1±0.8pg/ml) in (negative control). In conclusion, artemisinin has a role as antifungal and <italic>C. albicans</italic> infection causes the imbalance in immunity. |
| format | Article |
| id | doaj-art-730d136aaee24e1385484a942c89a898 |
| institution | Kabale University |
| issn | 1678-2690 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj-art-730d136aaee24e1385484a942c89a8982025-08-20T03:25:21ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902025-07-0197310.1590/0001-3765202520250187Gastrointestinal tract colonization with Candida albicans and mucosal immune response in mice treated with Artemisinin and Fluconazole orallySEENAA J. BADERhttps://orcid.org/0009-0004-7614-0090ATYAF S. HAMIEDhttps://orcid.org/0000-0001-7274-2394Abstract The results showed that after treating <italic>C. albicans</italic> with Artemisinin (0.104 mg/ml) for 3 hours the number of <italic>C. albicans</italic> decreased and affected the morphology hyphae and growth of <italic>Candida</italic> compared with Fluconazole (150 mg/ml) and control (infected mice). The biomarker levels in the tongue showed high levels of MDA and TGFβ (623±1.5pg/ml, 586.1±0.13pg/ml respectively) in (infected mice with fungi). IL-37 was recorded high level (49.21±0.21pg/ml) in (Neoral +Fungi + artemisinin + fluconazole) compared with negative control. The finding biomarker levels in stomach showed high levels of MDA and IL-37 (533.8±1.9, 69.76±0.39pg/ml) in (Neoral + Fungi + artemisinin + fluconazole) compared with control. TGF β was recorded high level (1002±0.32pg/ml) in (Neoral + Fungi + Artemisinin) compared with negative control. The biomarker levels in intestine showed high levels of MDA and TGFβ (1149±0.34pg/ml, 1089±0.3pg/ml respectively) in (mice infected with fungi). IL-37 was recorded high level (74.14±0.14pg/ml) in (Neoral + Fungi + artemisinin + fluconazole) compared with negative control (normal mice). The biomarker levels in serum showed high levels of MDA and TGFβ (1668±0.12 pg/ml, 1629±0.05 pg/ml respectively) in (mice infected with fungi) at (P<0.05). IL-37 was recorded high level (135.1±0.8pg/ml) in (negative control). In conclusion, artemisinin has a role as antifungal and <italic>C. albicans</italic> infection causes the imbalance in immunity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652025000300903&lng=en&tlng=enCandida albicansCyclosporinMDAL-37TGFβ |
| spellingShingle | SEENAA J. BADER ATYAF S. HAMIED Gastrointestinal tract colonization with Candida albicans and mucosal immune response in mice treated with Artemisinin and Fluconazole orally Anais da Academia Brasileira de Ciências Candida albicans Cyclosporin MDA L-37 TGFβ |
| title | Gastrointestinal tract colonization with Candida albicans and mucosal immune response in mice treated with Artemisinin and Fluconazole orally |
| title_full | Gastrointestinal tract colonization with Candida albicans and mucosal immune response in mice treated with Artemisinin and Fluconazole orally |
| title_fullStr | Gastrointestinal tract colonization with Candida albicans and mucosal immune response in mice treated with Artemisinin and Fluconazole orally |
| title_full_unstemmed | Gastrointestinal tract colonization with Candida albicans and mucosal immune response in mice treated with Artemisinin and Fluconazole orally |
| title_short | Gastrointestinal tract colonization with Candida albicans and mucosal immune response in mice treated with Artemisinin and Fluconazole orally |
| title_sort | gastrointestinal tract colonization with candida albicans and mucosal immune response in mice treated with artemisinin and fluconazole orally |
| topic | Candida albicans Cyclosporin MDA L-37 TGFβ |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652025000300903&lng=en&tlng=en |
| work_keys_str_mv | AT seenaajbader gastrointestinaltractcolonizationwithcandidaalbicansandmucosalimmuneresponseinmicetreatedwithartemisininandfluconazoleorally AT atyafshamied gastrointestinaltractcolonizationwithcandidaalbicansandmucosalimmuneresponseinmicetreatedwithartemisininandfluconazoleorally |