Cold-blooded vertebrates evolved regulatory B cells to participate in inflammatory diseases

Cold-blooded vertebrates evolved regulatory B cells to participate in inflammatory diseases

Abstract Background Regulatory B cell (Breg), known for its immunosuppressive properties through the provision of IL-10, plays a critical role in the control of inflammatory diseases. Although Breg has been discovered for over two decades in mammals, its existence in non-mammalian vertebrates remain...

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Main Authors: Jie Wang, Wen-Jing Dong, Tian-Tian Tian, Chang-Song Wu, Xiang-Yang Zhang, Ya-Zhen Hu, Yi-Ru Pan, Xue-Qing Han, Jun Li, Carolina Tafalla, Yong-An Zhang, Xu-Jie Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell Communication and Signaling
Subjects:
Regulatory B cell
IL-10
IL-35
Inflammatory bowel disease
Evolution
Online Access:https://doi.org/10.1186/s12964-025-02311-y
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