Unraveling Cathepsin S regulation in interleukin-7-mediated anti-tumor immunity reveals its targeting potential against oral cancer

Unraveling Cathepsin S regulation in interleukin-7-mediated anti-tumor immunity reveals its targeting potential against oral cancer

Abstract Background Immunomodulatory agents benefit a small percentage of patients with oral cancer (OC), a subset of head and neck cancer. Cathepsin S (CTSS), a lysosomal protease, has been frequently associated with tumor immunity. This study aimed to investigate the mechanism by which tumor CTSS...

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Main Authors: Yung-Chieh Chang, Szu-Jung Chen, Shang-Hung Chen, Sheng-Yen Hsiao, Li-Hsien Chen, Chung-Hsing Chen, Chan-Chuan Liu, Ya-Wen Chen, Ko-Jiunn Liu, Shang-Yin Wu, Jui-Mei Chu, Li-Ying Qiu, Wei-Fan Chiang, Hsing-Pang Hsieh, Wen-Yun Hsueh, Jenn-Ren Hsiao, Meng-Ru Shen, Jang-Yang Chang, Kwang-Yu Chang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Biomedical Science
Subjects:
Cathepsin S
Interleukin-7
Oral cancer
Tumor immunity
Immune checkpoint therapy
Online Access:https://doi.org/10.1186/s12929-025-01154-6
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