Evaluation of Antifungal Activity of MaxilloFacial Silicone Elastomer Reinforced with Chitosan Nanoparticles—An In vitro Study
Background: Microbial and fungal growth, particularly Candida albicans, is a major issue with the usage of maxillofacial silicone material, which can lead to chronic infection, inflammation, and silicone material degradation, for which the development of an antimicrobial silicone elastomer has becom...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_604_24 |
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| author | Ailneni Nivya Sri Shruti Vishal Dev Sonali Perti Nirmala Poddar Sourav Kumar Pati Pritam Das |
| author_facet | Ailneni Nivya Sri Shruti Vishal Dev Sonali Perti Nirmala Poddar Sourav Kumar Pati Pritam Das |
| author_sort | Ailneni Nivya Sri |
| collection | DOAJ |
| description | Background:
Microbial and fungal growth, particularly Candida albicans, is a major issue with the usage of maxillofacial silicone material, which can lead to chronic infection, inflammation, and silicone material degradation, for which the development of an antimicrobial silicone elastomer has become crucial.
Methodology:
This study was designed to determine the efficacy of adding chitosan nanoparticles (1.5%, 3%, and 5% by weight) to silicone matrix on antifungal activity. Eighty specimens were fabricated with varying concentrations of chitosan and separated into four groups [C1 (control), C2 (1.5%wt chitosan reinforced silicone), C3 (3%wt chitosan/silicone), and C4 (5%wt chitosan/silicone)]. An antifungal test was conducted on each group.
Results:
The inhibition zone was concentration dependent in antifungal tests; as the concentration increased, the inhibition zone grew as well.
Conclusion:
Improvement in the antifungal activity of silicone was demonstrated when chitosan nanoparticles were incorporated. |
| format | Article |
| id | doaj-art-730424308d904217a4a7b936afb5e2ea |
| institution | DOAJ |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-730424308d904217a4a7b936afb5e2ea2025-08-20T02:40:30ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S3239S324110.4103/jpbs.jpbs_604_24Evaluation of Antifungal Activity of MaxilloFacial Silicone Elastomer Reinforced with Chitosan Nanoparticles—An In vitro StudyAilneni Nivya SriShruti Vishal DevSonali PertiNirmala PoddarSourav Kumar PatiPritam DasBackground: Microbial and fungal growth, particularly Candida albicans, is a major issue with the usage of maxillofacial silicone material, which can lead to chronic infection, inflammation, and silicone material degradation, for which the development of an antimicrobial silicone elastomer has become crucial. Methodology: This study was designed to determine the efficacy of adding chitosan nanoparticles (1.5%, 3%, and 5% by weight) to silicone matrix on antifungal activity. Eighty specimens were fabricated with varying concentrations of chitosan and separated into four groups [C1 (control), C2 (1.5%wt chitosan reinforced silicone), C3 (3%wt chitosan/silicone), and C4 (5%wt chitosan/silicone)]. An antifungal test was conducted on each group. Results: The inhibition zone was concentration dependent in antifungal tests; as the concentration increased, the inhibition zone grew as well. Conclusion: Improvement in the antifungal activity of silicone was demonstrated when chitosan nanoparticles were incorporated.https://journals.lww.com/10.4103/jpbs.jpbs_604_24antifungal activitychitosan nanoparticlesmaxillofacial silicone elastomer |
| spellingShingle | Ailneni Nivya Sri Shruti Vishal Dev Sonali Perti Nirmala Poddar Sourav Kumar Pati Pritam Das Evaluation of Antifungal Activity of MaxilloFacial Silicone Elastomer Reinforced with Chitosan Nanoparticles—An In vitro Study Journal of Pharmacy and Bioallied Sciences antifungal activity chitosan nanoparticles maxillofacial silicone elastomer |
| title | Evaluation of Antifungal Activity of MaxilloFacial Silicone Elastomer Reinforced with Chitosan Nanoparticles—An In vitro Study |
| title_full | Evaluation of Antifungal Activity of MaxilloFacial Silicone Elastomer Reinforced with Chitosan Nanoparticles—An In vitro Study |
| title_fullStr | Evaluation of Antifungal Activity of MaxilloFacial Silicone Elastomer Reinforced with Chitosan Nanoparticles—An In vitro Study |
| title_full_unstemmed | Evaluation of Antifungal Activity of MaxilloFacial Silicone Elastomer Reinforced with Chitosan Nanoparticles—An In vitro Study |
| title_short | Evaluation of Antifungal Activity of MaxilloFacial Silicone Elastomer Reinforced with Chitosan Nanoparticles—An In vitro Study |
| title_sort | evaluation of antifungal activity of maxillofacial silicone elastomer reinforced with chitosan nanoparticles an in vitro study |
| topic | antifungal activity chitosan nanoparticles maxillofacial silicone elastomer |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_604_24 |
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