Dynamics of coagulation proteins upon ICU admission and after one year of recovery from COVID-19: a preliminary study
ObjectivesThis study aimed to investigate the association of baseline coagulation proteins with hospitalization variables in COVID-19 patients admitted to ICU, as well as coagulation system changes after one-year post-discharge, taking into account gender-specific bias in the coagulation profile.Met...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1489936/full |
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| author | Raquel Behar-Lagares Ana Virseda-Berdices Ana Virseda-Berdices Óscar Martínez-González Óscar Martínez-González Óscar Martínez-González Rafael Blancas Rafael Blancas Rafael Blancas Marcela Homez-Guzmán Eva Manteiga Juan Churruca-Sarasqueta Madian Manso-Álvarez Madian Manso-Álvarez Madian Manso-Álvarez Ángela Algaba Ángela Algaba Ángela Algaba Salvador Resino Salvador Resino Amanda Fernández-Rodríguez Amanda Fernández-Rodríguez María A. Jiménez-Sousa María A. Jiménez-Sousa |
| author_facet | Raquel Behar-Lagares Ana Virseda-Berdices Ana Virseda-Berdices Óscar Martínez-González Óscar Martínez-González Óscar Martínez-González Rafael Blancas Rafael Blancas Rafael Blancas Marcela Homez-Guzmán Eva Manteiga Juan Churruca-Sarasqueta Madian Manso-Álvarez Madian Manso-Álvarez Madian Manso-Álvarez Ángela Algaba Ángela Algaba Ángela Algaba Salvador Resino Salvador Resino Amanda Fernández-Rodríguez Amanda Fernández-Rodríguez María A. Jiménez-Sousa María A. Jiménez-Sousa |
| author_sort | Raquel Behar-Lagares |
| collection | DOAJ |
| description | ObjectivesThis study aimed to investigate the association of baseline coagulation proteins with hospitalization variables in COVID-19 patients admitted to ICU, as well as coagulation system changes after one-year post-discharge, taking into account gender-specific bias in the coagulation profile.MethodsWe conducted a prospective longitudinal study on 49 ICU-admitted COVID-19 patients. Proteins were measured using a Luminex 200™. The association between coagulation protein levels and hospitalization variables was carried out by generalized linear models adjusted by the most relevant covariates.ResultsAt ICU admission, lower factor XII, antithrombin, and protein C levels were linked to the need for invasive mechanical ventilation (IMV) or its duration (p=0.028; p=0.047 and p=0.015, respectively). Likewise, lower factor XII, antithrombin, and prothrombin levels were associated with longer ICU length of stay (ICU LOS) (p=0.045; p=0.022; p=0.036, respectively). From baseline to the end of the follow-up, factor XII, antithrombin, prothrombin, and protein C levels notably increased in patients with longer ICU LOS. One-year post-discharge, differences were found for factor IX, aPTT, and INR. Gender-stratified analysis showed sustained alterations in males.ConclusionsDepleted specific coagulation factors on ICU admission are associated with increased severity in critically ill COVID-19 patients. Most coagulation alterations recover one-year post-discharge, except for factor IX, aPTT and INR, which remain reduced. |
| format | Article |
| id | doaj-art-73038ee2effb4812980680ee9cb10e97 |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-73038ee2effb4812980680ee9cb10e972025-01-08T06:11:57ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-01-011410.3389/fcimb.2024.14899361489936Dynamics of coagulation proteins upon ICU admission and after one year of recovery from COVID-19: a preliminary studyRaquel Behar-Lagares0Ana Virseda-Berdices1Ana Virseda-Berdices2Óscar Martínez-González3Óscar Martínez-González4Óscar Martínez-González5Rafael Blancas6Rafael Blancas7Rafael Blancas8Marcela Homez-Guzmán9Eva Manteiga10Juan Churruca-Sarasqueta11Madian Manso-Álvarez12Madian Manso-Álvarez13Madian Manso-Álvarez14Ángela Algaba15Ángela Algaba16Ángela Algaba17Salvador Resino18Salvador Resino19Amanda Fernández-Rodríguez20Amanda Fernández-Rodríguez21María A. Jiménez-Sousa22María A. Jiménez-Sousa23Unit of Viral Infection and Immunity, National Center for Microbiology (CNM), Health Institute Carlos III (ISCIII), Majadahonda, Madrid, SpainUnit of Viral Infection and Immunity, National Center for Microbiology (CNM), Health Institute Carlos III (ISCIII), Majadahonda, Madrid, SpainCentro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, SpainCritical Care Department, Hospital Universitario del Tajo, Aranjuez, Madrid, SpainUniversidad Alfonso X el Sabio, Villanueva de la Cañada, Madrid, SpainFundación para la Investigación e Innovación Biomédica del Hospital Universitario Infanta Sofía y Hospital Universitario del Henares (FIB HUIS HHEN), San Sebastián de los Reyes, Madrid, SpainCritical Care Department, Hospital Universitario del Tajo, Aranjuez, Madrid, SpainUniversidad Alfonso X el Sabio, Villanueva de la Cañada, Madrid, SpainFundación para la Investigación e Innovación Biomédica del Hospital Universitario Infanta Sofía y Hospital Universitario del Henares (FIB HUIS HHEN), San Sebastián de los Reyes, Madrid, SpainCritical Care Department, Hospital Universitario Infanta Cristina, Parla, Madrid, SpainCritical Care Department, Hospital Universitario Infanta Cristina, Parla, Madrid, SpainHaematology and Haemostasis Department, University Hospital Infanta Leonor, Madrid, SpainCritical Care Department, Hospital Universitario del Tajo, Aranjuez, Madrid, SpainUniversidad Alfonso X el Sabio, Villanueva de la Cañada, Madrid, SpainFundación para la Investigación e Innovación Biomédica del Hospital Universitario Infanta Sofía y Hospital Universitario del Henares (FIB HUIS HHEN), San Sebastián de los Reyes, Madrid, SpainCritical Care Department, Hospital Universitario del Tajo, Aranjuez, Madrid, SpainUniversidad Alfonso X el Sabio, Villanueva de la Cañada, Madrid, SpainFundación para la Investigación e Innovación Biomédica del Hospital Universitario Infanta Sofía y Hospital Universitario del Henares (FIB HUIS HHEN), San Sebastián de los Reyes, Madrid, SpainUnit of Viral Infection and Immunity, National Center for Microbiology (CNM), Health Institute Carlos III (ISCIII), Majadahonda, Madrid, SpainCentro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, SpainUnit of Viral Infection and Immunity, National Center for Microbiology (CNM), Health Institute Carlos III (ISCIII), Majadahonda, Madrid, SpainCentro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, SpainUnit of Viral Infection and Immunity, National Center for Microbiology (CNM), Health Institute Carlos III (ISCIII), Majadahonda, Madrid, SpainCentro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, SpainObjectivesThis study aimed to investigate the association of baseline coagulation proteins with hospitalization variables in COVID-19 patients admitted to ICU, as well as coagulation system changes after one-year post-discharge, taking into account gender-specific bias in the coagulation profile.MethodsWe conducted a prospective longitudinal study on 49 ICU-admitted COVID-19 patients. Proteins were measured using a Luminex 200™. The association between coagulation protein levels and hospitalization variables was carried out by generalized linear models adjusted by the most relevant covariates.ResultsAt ICU admission, lower factor XII, antithrombin, and protein C levels were linked to the need for invasive mechanical ventilation (IMV) or its duration (p=0.028; p=0.047 and p=0.015, respectively). Likewise, lower factor XII, antithrombin, and prothrombin levels were associated with longer ICU length of stay (ICU LOS) (p=0.045; p=0.022; p=0.036, respectively). From baseline to the end of the follow-up, factor XII, antithrombin, prothrombin, and protein C levels notably increased in patients with longer ICU LOS. One-year post-discharge, differences were found for factor IX, aPTT, and INR. Gender-stratified analysis showed sustained alterations in males.ConclusionsDepleted specific coagulation factors on ICU admission are associated with increased severity in critically ill COVID-19 patients. Most coagulation alterations recover one-year post-discharge, except for factor IX, aPTT and INR, which remain reduced.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1489936/fullSARS-CoV2COVID-19 severitybiomarkerscoagulationhospitalizationICU |
| spellingShingle | Raquel Behar-Lagares Ana Virseda-Berdices Ana Virseda-Berdices Óscar Martínez-González Óscar Martínez-González Óscar Martínez-González Rafael Blancas Rafael Blancas Rafael Blancas Marcela Homez-Guzmán Eva Manteiga Juan Churruca-Sarasqueta Madian Manso-Álvarez Madian Manso-Álvarez Madian Manso-Álvarez Ángela Algaba Ángela Algaba Ángela Algaba Salvador Resino Salvador Resino Amanda Fernández-Rodríguez Amanda Fernández-Rodríguez María A. Jiménez-Sousa María A. Jiménez-Sousa Dynamics of coagulation proteins upon ICU admission and after one year of recovery from COVID-19: a preliminary study Frontiers in Cellular and Infection Microbiology SARS-CoV2 COVID-19 severity biomarkers coagulation hospitalization ICU |
| title | Dynamics of coagulation proteins upon ICU admission and after one year of recovery from COVID-19: a preliminary study |
| title_full | Dynamics of coagulation proteins upon ICU admission and after one year of recovery from COVID-19: a preliminary study |
| title_fullStr | Dynamics of coagulation proteins upon ICU admission and after one year of recovery from COVID-19: a preliminary study |
| title_full_unstemmed | Dynamics of coagulation proteins upon ICU admission and after one year of recovery from COVID-19: a preliminary study |
| title_short | Dynamics of coagulation proteins upon ICU admission and after one year of recovery from COVID-19: a preliminary study |
| title_sort | dynamics of coagulation proteins upon icu admission and after one year of recovery from covid 19 a preliminary study |
| topic | SARS-CoV2 COVID-19 severity biomarkers coagulation hospitalization ICU |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1489936/full |
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