Umbilical cord mesenchymal stem cell exosomal miR-143-3p delays endothelial cell senescence through targeting COX-2.

Umbilical cord mesenchymal stem cell exosomal miR-143-3p delays endothelial cell senescence through targeting COX-2.

Senescence of vascular endothelial cells leads to endothelial dysfunction and exacerbates atherosclerosis. In this study, we presented evidence that exosomes derived from human umbilical cord mesenchymal stem cells (hucMSC-Exos) could delay endothelial cell senescence, promote endothelial cell proli...

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Main Authors: Zhi-Peng Yang, Shui-Hong Lu, Yan-Hong Pan, Zhao-Fu Liao, Yi-Tuan Xie, Heng Li, Yu-Lan Zhou, Zhen-Can Shi, Yun-Fei Qu, Zhu-Guo Wu, Chongxiang Xiong, Xing-Dong Xiong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0327173
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