Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia
Background and Objectives. Community-acquired pneumonia (CAP) has a high mortality rate among adult patients throughout the world. The highest mortality is registered in the older age group with a steady increase in the number of cases of morbidity among persons of working age. Neutrophils are one o...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/4897038 |
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| author | Vilen Molotov-Luchanskiy Altynbek Nukhuly Larissa Muravlyova Ryszhan Bakirova Aruna Kossybayeva Dmitry Klyuyev Ludmila Demidchik Irina Beinikova |
| author_facet | Vilen Molotov-Luchanskiy Altynbek Nukhuly Larissa Muravlyova Ryszhan Bakirova Aruna Kossybayeva Dmitry Klyuyev Ludmila Demidchik Irina Beinikova |
| author_sort | Vilen Molotov-Luchanskiy |
| collection | DOAJ |
| description | Background and Objectives. Community-acquired pneumonia (CAP) has a high mortality rate among adult patients throughout the world. The highest mortality is registered in the older age group with a steady increase in the number of cases of morbidity among persons of working age. Neutrophils are one of the most urgent areas of research, since their condition largely determines the development and outcome of acute pneumonia. We study the indices of oxidative stress and oxidized-modified proteins of neutrophils in CAP patients, depending on the degree of severity, and also compare the detection frequency of neutrophil extracellular traps in the progression of pneumonia. Materials and Methods. 51 patients with CAP were divided into 2 groups depending on the severity of the pathological process. The first group (I) consisted of 32 patients with moderate severity of pneumonia. The second group (II) consisted of 19 patients with severe pneumonia. The third group (III), the comparison group, consisted of 14 CAP patients with chronic obstructive pulmonary disease (COPD). The control group consisted of 19 volunteers. Results. Statistically significant increase in the level of carbonyl derivatives (CD) in patients of all study groups relative to the control group was revealed. In the group of patients with moderate severity and severe pneumonia, also in CAP patients with COPD, the level of CD exceeded the control group. There was no statistically significant difference in the level of advanced oxidation protein products (AOPP) and myeloperoxidase (MPO) in blood neutrophils between the studied groups. Conclusion. Results indicate an oxidative imbalance in neutrophils and contribute to the worsening of the course of the disease. |
| format | Article |
| id | doaj-art-72ffe73735324298bfac537c60743237 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-72ffe73735324298bfac537c607432372025-02-03T01:05:05ZengWileyPulmonary Medicine2090-18362090-18442020-01-01202010.1155/2020/48970384897038Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired PneumoniaVilen Molotov-Luchanskiy0Altynbek Nukhuly1Larissa Muravlyova2Ryszhan Bakirova3Aruna Kossybayeva4Dmitry Klyuyev5Ludmila Demidchik6Irina Beinikova7“Karaganda Medical University” Non-commercial Joint-Stock Company, KazakhstanPavlodar State Pedagogical University, Kazakhstan“Karaganda Medical University” Non-commercial Joint-Stock Company, Kazakhstan“Karaganda Medical University” Non-commercial Joint-Stock Company, Kazakhstan“Karaganda Medical University” Non-commercial Joint-Stock Company, Kazakhstan“Karaganda Medical University” Non-commercial Joint-Stock Company, Kazakhstan“Karaganda Medical University” Non-commercial Joint-Stock Company, Kazakhstan“Karaganda Medical University” Non-commercial Joint-Stock Company, KazakhstanBackground and Objectives. Community-acquired pneumonia (CAP) has a high mortality rate among adult patients throughout the world. The highest mortality is registered in the older age group with a steady increase in the number of cases of morbidity among persons of working age. Neutrophils are one of the most urgent areas of research, since their condition largely determines the development and outcome of acute pneumonia. We study the indices of oxidative stress and oxidized-modified proteins of neutrophils in CAP patients, depending on the degree of severity, and also compare the detection frequency of neutrophil extracellular traps in the progression of pneumonia. Materials and Methods. 51 patients with CAP were divided into 2 groups depending on the severity of the pathological process. The first group (I) consisted of 32 patients with moderate severity of pneumonia. The second group (II) consisted of 19 patients with severe pneumonia. The third group (III), the comparison group, consisted of 14 CAP patients with chronic obstructive pulmonary disease (COPD). The control group consisted of 19 volunteers. Results. Statistically significant increase in the level of carbonyl derivatives (CD) in patients of all study groups relative to the control group was revealed. In the group of patients with moderate severity and severe pneumonia, also in CAP patients with COPD, the level of CD exceeded the control group. There was no statistically significant difference in the level of advanced oxidation protein products (AOPP) and myeloperoxidase (MPO) in blood neutrophils between the studied groups. Conclusion. Results indicate an oxidative imbalance in neutrophils and contribute to the worsening of the course of the disease.http://dx.doi.org/10.1155/2020/4897038 |
| spellingShingle | Vilen Molotov-Luchanskiy Altynbek Nukhuly Larissa Muravlyova Ryszhan Bakirova Aruna Kossybayeva Dmitry Klyuyev Ludmila Demidchik Irina Beinikova Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia Pulmonary Medicine |
| title | Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia |
| title_full | Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia |
| title_fullStr | Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia |
| title_full_unstemmed | Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia |
| title_short | Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia |
| title_sort | neutrophil oxidized modified proteins and neutrophil extracellular traps in patients with community acquired pneumonia |
| url | http://dx.doi.org/10.1155/2020/4897038 |
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