Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma

Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma

Abstract Oncolytic viruses (OVs) hold promise for cancer treatment. However, the antitumor efficacy is limited. Microbiota plays a pivotal role in cancer treatment and its impact on oncolytic virotherapy is unknown. Here, we show that VSVΔ51 has higher antitumor efficacy for hepatocellular carcinoma...

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Main Authors: Jiayu Zhang, Jinneng Yang, Jinyan Luo, Weili Wu, Haidan Luo, Wenxia Wei, Haimei Lyu, Yuzhi Wang, Hairong Yi, Yijing Zhang, Zongmin Fan, Haiwen Lyu, Vishnu Priya Kanakaveti, Baifu Qin, Ping Yuan, Runxiang Yang, Haipeng Zhang, Tao Zuo, Dean W. Felsher, Mong-Hong Lee, Kai Li
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58407-z
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