β-Glucan Subverts the Function of Myeloid Cells in Neonates
β-Glucan is the main component of the cell wall of pathogen-associated molecular patterns (PAMPs) including various yeast, fungi, or certain bacteria. Previous reports demonstrated that β-glucan was widely investigated as a potent immunomodulators to stimulate innate and adaptive immune responses, w...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2024/2765001 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849414530584543232 |
|---|---|
| author | Yingying Chen Hui Li Lin Zhu Quan Yang Jie Zhou |
| author_facet | Yingying Chen Hui Li Lin Zhu Quan Yang Jie Zhou |
| author_sort | Yingying Chen |
| collection | DOAJ |
| description | β-Glucan is the main component of the cell wall of pathogen-associated molecular patterns (PAMPs) including various yeast, fungi, or certain bacteria. Previous reports demonstrated that β-glucan was widely investigated as a potent immunomodulators to stimulate innate and adaptive immune responses, which indicated that it could be recommended as an effective adjuvant in immunotherapy. However, the detailed effects of β-glucan on neonatal immunity are still largely unknown. Here, we found that β-glucan did not affect the frequencies and numbers of myeloid cells in the spleen and bone marrow from neonates. Functional assay revealed that β-glucan from neonates compromised the immunosuppressive function of immature myeloid cells, which were myeloid-derived suppressor cells (MDSCs). Flow cytometry or gene expression analysis revealed that β-glucan-derived polymorphonuclear (PMN)-MDSCs produced lower level of reactive oxygen species (ROS) and arginase-1 (Arg1) in neonatal mice. Furthermore, β-glucan administration significantly decreased the frequency and ROS level of PMN-MDSCs in vitro. These observations suggest that β-glucan facilitates the maturation of myeloid cells in early life, which may contribute to its beneficial effects against immune disorders later in life. |
| format | Article |
| id | doaj-art-72fa759f2f1341a58245cc4c6e46e2cf |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-72fa759f2f1341a58245cc4c6e46e2cf2025-08-20T03:33:49ZengWileyJournal of Immunology Research2314-71562024-01-01202410.1155/2024/2765001β-Glucan Subverts the Function of Myeloid Cells in NeonatesYingying Chen0Hui Li1Lin Zhu2Quan Yang3Jie Zhou4Key Laboratory of ImmunologyTianjin Institute of ImmunologyTianjin Institute of ImmunologyKey Laboratory of ImmunologyTianjin Institute of Immunologyβ-Glucan is the main component of the cell wall of pathogen-associated molecular patterns (PAMPs) including various yeast, fungi, or certain bacteria. Previous reports demonstrated that β-glucan was widely investigated as a potent immunomodulators to stimulate innate and adaptive immune responses, which indicated that it could be recommended as an effective adjuvant in immunotherapy. However, the detailed effects of β-glucan on neonatal immunity are still largely unknown. Here, we found that β-glucan did not affect the frequencies and numbers of myeloid cells in the spleen and bone marrow from neonates. Functional assay revealed that β-glucan from neonates compromised the immunosuppressive function of immature myeloid cells, which were myeloid-derived suppressor cells (MDSCs). Flow cytometry or gene expression analysis revealed that β-glucan-derived polymorphonuclear (PMN)-MDSCs produced lower level of reactive oxygen species (ROS) and arginase-1 (Arg1) in neonatal mice. Furthermore, β-glucan administration significantly decreased the frequency and ROS level of PMN-MDSCs in vitro. These observations suggest that β-glucan facilitates the maturation of myeloid cells in early life, which may contribute to its beneficial effects against immune disorders later in life.http://dx.doi.org/10.1155/2024/2765001 |
| spellingShingle | Yingying Chen Hui Li Lin Zhu Quan Yang Jie Zhou β-Glucan Subverts the Function of Myeloid Cells in Neonates Journal of Immunology Research |
| title | β-Glucan Subverts the Function of Myeloid Cells in Neonates |
| title_full | β-Glucan Subverts the Function of Myeloid Cells in Neonates |
| title_fullStr | β-Glucan Subverts the Function of Myeloid Cells in Neonates |
| title_full_unstemmed | β-Glucan Subverts the Function of Myeloid Cells in Neonates |
| title_short | β-Glucan Subverts the Function of Myeloid Cells in Neonates |
| title_sort | β glucan subverts the function of myeloid cells in neonates |
| url | http://dx.doi.org/10.1155/2024/2765001 |
| work_keys_str_mv | AT yingyingchen bglucansubvertsthefunctionofmyeloidcellsinneonates AT huili bglucansubvertsthefunctionofmyeloidcellsinneonates AT linzhu bglucansubvertsthefunctionofmyeloidcellsinneonates AT quanyang bglucansubvertsthefunctionofmyeloidcellsinneonates AT jiezhou bglucansubvertsthefunctionofmyeloidcellsinneonates |