Smoking Status Modifies the Relationship between Th2 Biomarkers and Small Airway Obstruction in Asthma
Background. Cigarette smoking and Th2-inflammation are both crucial in the pathogenesis of asthma. However, it is unknown whether smoking can affect the association between Th2-inflammation and small airway obstruction in adults with asthma. Methods. Adults diagnosed with asthma by a pulmonologist a...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2021/1918518 |
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| author | Shuyuan Chu Libing Ma Jianghong Wei Jiying Wang Qing Xu Meixi Chen Ming Jiang Miao Luo Jingjie Wu Lin Mai Guofang Tang Biwen Mo |
| author_facet | Shuyuan Chu Libing Ma Jianghong Wei Jiying Wang Qing Xu Meixi Chen Ming Jiang Miao Luo Jingjie Wu Lin Mai Guofang Tang Biwen Mo |
| author_sort | Shuyuan Chu |
| collection | DOAJ |
| description | Background. Cigarette smoking and Th2-inflammation are both crucial in the pathogenesis of asthma. However, it is unknown whether smoking can affect the association between Th2-inflammation and small airway obstruction in adults with asthma. Methods. Adults diagnosed with asthma by a pulmonologist according to Global Initiative for Asthma guidelines were recruited from September 2016 to April 2018 to participate in this study. Participants were divided into two groups, the small airway obstruction group (those with FEF25–75% predicted value ≤ 65%) and the normal small airway function group (those with FEF25–75% predicted value > 65%). Final data analysis included 385 and 93 people in the Obstructive Group and the Normal Group, respectively. Total serum IgE level and blood eosinophil count were used as biomarkers of the Th2 phenotype. Results. The Obstructive Group had a larger fraction of smokers, higher blood eosinophil count, and lower lung function than the Normal Group. Current-smoking status was associated with an increased risk of small airway obstruction (adjusted odds ratio = 4.677, 95% confidence interval [1.593–13.730]); and log-IgE level was associated with a decreased risk of small airway obstruction (0.403 [0.216–0.754]). Smoking status stratified analysis showed an association between log-IgE level and a decreased risk of small airway obstruction only in never-smoker asthmatics (0.487 [0.249–0.954]). Conclusions. Current-smoking status and total serum IgE are, respectively, associated with small airway obstruction. Smoking status modifies the relationship between Th2 biomarkers and small airway function. These findings contribute to the understanding of risk factors associated with asthma endotyping. |
| format | Article |
| id | doaj-art-72f892c9d9ee4ea0aed3b0dfd28d209a |
| institution | OA Journals |
| issn | 1916-7245 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-72f892c9d9ee4ea0aed3b0dfd28d209a2025-08-20T02:06:16ZengWileyCanadian Respiratory Journal1916-72452021-01-01202110.1155/2021/1918518Smoking Status Modifies the Relationship between Th2 Biomarkers and Small Airway Obstruction in AsthmaShuyuan Chu0Libing Ma1Jianghong Wei2Jiying Wang3Qing Xu4Meixi Chen5Ming Jiang6Miao Luo7Jingjie Wu8Lin Mai9Guofang Tang10Biwen Mo11Department of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineBackground. Cigarette smoking and Th2-inflammation are both crucial in the pathogenesis of asthma. However, it is unknown whether smoking can affect the association between Th2-inflammation and small airway obstruction in adults with asthma. Methods. Adults diagnosed with asthma by a pulmonologist according to Global Initiative for Asthma guidelines were recruited from September 2016 to April 2018 to participate in this study. Participants were divided into two groups, the small airway obstruction group (those with FEF25–75% predicted value ≤ 65%) and the normal small airway function group (those with FEF25–75% predicted value > 65%). Final data analysis included 385 and 93 people in the Obstructive Group and the Normal Group, respectively. Total serum IgE level and blood eosinophil count were used as biomarkers of the Th2 phenotype. Results. The Obstructive Group had a larger fraction of smokers, higher blood eosinophil count, and lower lung function than the Normal Group. Current-smoking status was associated with an increased risk of small airway obstruction (adjusted odds ratio = 4.677, 95% confidence interval [1.593–13.730]); and log-IgE level was associated with a decreased risk of small airway obstruction (0.403 [0.216–0.754]). Smoking status stratified analysis showed an association between log-IgE level and a decreased risk of small airway obstruction only in never-smoker asthmatics (0.487 [0.249–0.954]). Conclusions. Current-smoking status and total serum IgE are, respectively, associated with small airway obstruction. Smoking status modifies the relationship between Th2 biomarkers and small airway function. These findings contribute to the understanding of risk factors associated with asthma endotyping.http://dx.doi.org/10.1155/2021/1918518 |
| spellingShingle | Shuyuan Chu Libing Ma Jianghong Wei Jiying Wang Qing Xu Meixi Chen Ming Jiang Miao Luo Jingjie Wu Lin Mai Guofang Tang Biwen Mo Smoking Status Modifies the Relationship between Th2 Biomarkers and Small Airway Obstruction in Asthma Canadian Respiratory Journal |
| title | Smoking Status Modifies the Relationship between Th2 Biomarkers and Small Airway Obstruction in Asthma |
| title_full | Smoking Status Modifies the Relationship between Th2 Biomarkers and Small Airway Obstruction in Asthma |
| title_fullStr | Smoking Status Modifies the Relationship between Th2 Biomarkers and Small Airway Obstruction in Asthma |
| title_full_unstemmed | Smoking Status Modifies the Relationship between Th2 Biomarkers and Small Airway Obstruction in Asthma |
| title_short | Smoking Status Modifies the Relationship between Th2 Biomarkers and Small Airway Obstruction in Asthma |
| title_sort | smoking status modifies the relationship between th2 biomarkers and small airway obstruction in asthma |
| url | http://dx.doi.org/10.1155/2021/1918518 |
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