The processes of the catalytic cycle of the cytochrome system associated with its activation by means of the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase
The paper presents a theoretical study of the molecular mechanism of activation of the cytochrome P450 system by the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase in the catalytic cycle. The relevance of studying cytochrome P450 enzymes and their activator is...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2025-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2025/32/bioconf_esdca2025_01026.pdf |
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| author | Popova Olga Bylinskaya Daria Nikitina Anastasia Ukrainskaya Olga |
| author_facet | Popova Olga Bylinskaya Daria Nikitina Anastasia Ukrainskaya Olga |
| author_sort | Popova Olga |
| collection | DOAJ |
| description | The paper presents a theoretical study of the molecular mechanism of activation of the cytochrome P450 system by the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase in the catalytic cycle. The relevance of studying cytochrome P450 enzymes and their activator is determined by the development of methods for effective diagnostics of hepatobiliary pathologies. It was found that the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase functions as a redox “partner” for cytochromes P450. An electrochemical method used to study the monooxygenase system of microsomal oxidation is described. Proposals for further study of the cytochrome system, as well as the possibility of their application in practice are put forward. This is of particular interest to veterinary pharmacology, which is dictated by the trend towards an increase in the use of drugs, as well as the deterioration of environmental conditions in general. |
| format | Article |
| id | doaj-art-72f86d0ff78b468987e718fa0cbd25ff |
| institution | OA Journals |
| issn | 2117-4458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-72f86d0ff78b468987e718fa0cbd25ff2025-08-20T02:09:25ZengEDP SciencesBIO Web of Conferences2117-44582025-01-011810102610.1051/bioconf/202518101026bioconf_esdca2025_01026The processes of the catalytic cycle of the cytochrome system associated with its activation by means of the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductasePopova Olga0Bylinskaya Daria1Nikitina Anastasia2Ukrainskaya Olga3Federal State Budgetary Educational Institution of Higher Education “Saint Petersburg State University of Veterinary Medicine”Federal State Budgetary Educational Institution of Higher Education “Saint Petersburg State University of Veterinary Medicine”Federal State Budgetary Educational Institution of Higher Education “Saint Petersburg State University of Veterinary Medicine”Federal State Budgetary Educational Institution of Higher Education “Saint Petersburg State University of Veterinary Medicine”The paper presents a theoretical study of the molecular mechanism of activation of the cytochrome P450 system by the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase in the catalytic cycle. The relevance of studying cytochrome P450 enzymes and their activator is determined by the development of methods for effective diagnostics of hepatobiliary pathologies. It was found that the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase functions as a redox “partner” for cytochromes P450. An electrochemical method used to study the monooxygenase system of microsomal oxidation is described. Proposals for further study of the cytochrome system, as well as the possibility of their application in practice are put forward. This is of particular interest to veterinary pharmacology, which is dictated by the trend towards an increase in the use of drugs, as well as the deterioration of environmental conditions in general.https://www.bio-conferences.org/articles/bioconf/pdf/2025/32/bioconf_esdca2025_01026.pdf |
| spellingShingle | Popova Olga Bylinskaya Daria Nikitina Anastasia Ukrainskaya Olga The processes of the catalytic cycle of the cytochrome system associated with its activation by means of the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase BIO Web of Conferences |
| title | The processes of the catalytic cycle of the cytochrome system associated with its activation by means of the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase |
| title_full | The processes of the catalytic cycle of the cytochrome system associated with its activation by means of the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase |
| title_fullStr | The processes of the catalytic cycle of the cytochrome system associated with its activation by means of the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase |
| title_full_unstemmed | The processes of the catalytic cycle of the cytochrome system associated with its activation by means of the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase |
| title_short | The processes of the catalytic cycle of the cytochrome system associated with its activation by means of the enzyme Nicotinamide-β-adenine dinucleotide phosphate-H-ferrihemoprotein oxidoreductase |
| title_sort | processes of the catalytic cycle of the cytochrome system associated with its activation by means of the enzyme nicotinamide β adenine dinucleotide phosphate h ferrihemoprotein oxidoreductase |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2025/32/bioconf_esdca2025_01026.pdf |
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