Pharmaceutical Applications of Glucose Syrup from High Quality Cassava Flour in Oral Liquid Formulations
Pharmaceutical oral solutions are preparations in which the active ingredients are dissolved in suitable liquid vehicles such as syrups. This study sought to determine the potential of glucose syrup produced from high quality cassava flour (HQCF) as a vehicle or sweetener in the preparation of parac...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Food Science |
| Online Access: | http://dx.doi.org/10.1155/2022/6869122 |
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| author | Ivan K. Simpson Frederick W. A. Owusu Mariam E. Boakye-Gyasi Philomena Entsie Marcel T. Bayor Kwabena Ofori-Kwakye |
| author_facet | Ivan K. Simpson Frederick W. A. Owusu Mariam E. Boakye-Gyasi Philomena Entsie Marcel T. Bayor Kwabena Ofori-Kwakye |
| author_sort | Ivan K. Simpson |
| collection | DOAJ |
| description | Pharmaceutical oral solutions are preparations in which the active ingredients are dissolved in suitable liquid vehicles such as syrups. This study sought to determine the potential of glucose syrup produced from high quality cassava flour (HQCF) as a vehicle or sweetener in the preparation of paracetamol syrup and simple linctus. Four formulations (two paracetamol syrups (B1 and B2) and two simple linctus formulations (A1 and A2)) were prepared using glucose syrup from HQCF as vehicle or sweetener while two controls (B3 and A3) were prepared for each group using sucrose syrup as vehicle or sweetener. Two brands of paracetamol syrup and simple linctus were purchased from retail pharmacies to serve as standards. Physical and organoleptic parameters such as pH, taste and color, microbial load, and drug content of all formulations were determined. All formulations passed the microbial load and drug content tests as specified by the British Pharmacopoeia. The paracetamol syrups were all sweet with characteristic bitter aftertastes except formulation B2 which was sweetened with sucralose. All the simple linctus formulations were sweet except A2 (sweetened with sucralose) which was very sweet. The taste masking capacity of the glucose syrup produced from HQCF matched that of the sucrose syrup in the products formulated. Therefore, glucose syrup from HQCF could be a suitable alternative to sucrose syrup as a vehicle or sweetener in oral liquid formulations and can ultimately reduce the cost of these oral liquid formulations. |
| format | Article |
| id | doaj-art-72f083b48f6e4d4592ba834b8409f297 |
| institution | Kabale University |
| issn | 2314-5765 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Food Science |
| spelling | doaj-art-72f083b48f6e4d4592ba834b8409f2972025-02-03T00:59:08ZengWileyInternational Journal of Food Science2314-57652022-01-01202210.1155/2022/6869122Pharmaceutical Applications of Glucose Syrup from High Quality Cassava Flour in Oral Liquid FormulationsIvan K. Simpson0Frederick W. A. Owusu1Mariam E. Boakye-Gyasi2Philomena Entsie3Marcel T. Bayor4Kwabena Ofori-Kwakye5Department of PharmaceuticsDepartment of PharmaceuticsDepartment of PharmaceuticsDepartment of Herbal MedicineDepartment of PharmaceuticsDepartment of PharmaceuticsPharmaceutical oral solutions are preparations in which the active ingredients are dissolved in suitable liquid vehicles such as syrups. This study sought to determine the potential of glucose syrup produced from high quality cassava flour (HQCF) as a vehicle or sweetener in the preparation of paracetamol syrup and simple linctus. Four formulations (two paracetamol syrups (B1 and B2) and two simple linctus formulations (A1 and A2)) were prepared using glucose syrup from HQCF as vehicle or sweetener while two controls (B3 and A3) were prepared for each group using sucrose syrup as vehicle or sweetener. Two brands of paracetamol syrup and simple linctus were purchased from retail pharmacies to serve as standards. Physical and organoleptic parameters such as pH, taste and color, microbial load, and drug content of all formulations were determined. All formulations passed the microbial load and drug content tests as specified by the British Pharmacopoeia. The paracetamol syrups were all sweet with characteristic bitter aftertastes except formulation B2 which was sweetened with sucralose. All the simple linctus formulations were sweet except A2 (sweetened with sucralose) which was very sweet. The taste masking capacity of the glucose syrup produced from HQCF matched that of the sucrose syrup in the products formulated. Therefore, glucose syrup from HQCF could be a suitable alternative to sucrose syrup as a vehicle or sweetener in oral liquid formulations and can ultimately reduce the cost of these oral liquid formulations.http://dx.doi.org/10.1155/2022/6869122 |
| spellingShingle | Ivan K. Simpson Frederick W. A. Owusu Mariam E. Boakye-Gyasi Philomena Entsie Marcel T. Bayor Kwabena Ofori-Kwakye Pharmaceutical Applications of Glucose Syrup from High Quality Cassava Flour in Oral Liquid Formulations International Journal of Food Science |
| title | Pharmaceutical Applications of Glucose Syrup from High Quality Cassava Flour in Oral Liquid Formulations |
| title_full | Pharmaceutical Applications of Glucose Syrup from High Quality Cassava Flour in Oral Liquid Formulations |
| title_fullStr | Pharmaceutical Applications of Glucose Syrup from High Quality Cassava Flour in Oral Liquid Formulations |
| title_full_unstemmed | Pharmaceutical Applications of Glucose Syrup from High Quality Cassava Flour in Oral Liquid Formulations |
| title_short | Pharmaceutical Applications of Glucose Syrup from High Quality Cassava Flour in Oral Liquid Formulations |
| title_sort | pharmaceutical applications of glucose syrup from high quality cassava flour in oral liquid formulations |
| url | http://dx.doi.org/10.1155/2022/6869122 |
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