Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic Diseases
Postprandial hyperlipidemia with accumulation of remnant lipoproteins is a common metabolic disturbance associated with atherosclerosis and vascular dysfunction, particularly during chronic disease states such as obesity, the metabolic syndrome and, diabetes. Remnant lipoproteins become attached to...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/947417 |
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| author | Boudewijn Klop Spencer D. Proctor John C. Mamo Kathleen M. Botham Manuel Castro Cabezas |
| author_facet | Boudewijn Klop Spencer D. Proctor John C. Mamo Kathleen M. Botham Manuel Castro Cabezas |
| author_sort | Boudewijn Klop |
| collection | DOAJ |
| description | Postprandial hyperlipidemia with accumulation of remnant lipoproteins is a common metabolic disturbance associated with atherosclerosis and vascular dysfunction, particularly during chronic disease states such as obesity, the metabolic syndrome and, diabetes. Remnant lipoproteins become attached to the vascular wall, where they can penetrate intact endothelium causing foam cell formation. Postprandial remnant lipoproteins can activate circulating leukocytes, upregulate the expression of endothelial adhesion molecules, facilitate adhesion and migration of inflammatory cells into the subendothelial space, and activate the complement system. Since humans are postprandial most of the day, the continuous generation of remnants after each meal may be one of the triggers for the development of atherosclerosis. Modulation of postprandial lipemia by lifestyle changes and pharmacological interventions could result in a further decrease of cardiovascular mortality and morbidity. This paper will provide an update on current concepts concerning the relationship between postprandial lipemia, inflammation, vascular function, and therapeutic options. |
| format | Article |
| id | doaj-art-72ec39e6e4904eeaaf5ace94a74adcbf |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-72ec39e6e4904eeaaf5ace94a74adcbf2025-08-20T03:33:50ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322012-01-01201210.1155/2012/947417947417Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic DiseasesBoudewijn Klop0Spencer D. Proctor1John C. Mamo2Kathleen M. Botham3Manuel Castro Cabezas4Department of Internal Medicine, Center for Diabetes and Vascular Medicine, Sint Franciscus Gasthuis, 3004 BA Rotterdam, The NetherlandsMetabolic and Cardiovascular Diseases Lab, Molecular Cell Biology of Lipids Group, Alberta Diabetes and Mazankowski Alberta Heart Institutes, University of Alberta, Edmonton, AB, T6g 2R3, CanadaFaculty of Health Sciences, Curtin University, Perth and Sydney, WA 6102, AustraliaDepartment Of Veterinary Basic Sciences, The Royal Veterinary College, London NW1 0TU, UKDepartment of Internal Medicine, Center for Diabetes and Vascular Medicine, Sint Franciscus Gasthuis, 3004 BA Rotterdam, The NetherlandsPostprandial hyperlipidemia with accumulation of remnant lipoproteins is a common metabolic disturbance associated with atherosclerosis and vascular dysfunction, particularly during chronic disease states such as obesity, the metabolic syndrome and, diabetes. Remnant lipoproteins become attached to the vascular wall, where they can penetrate intact endothelium causing foam cell formation. Postprandial remnant lipoproteins can activate circulating leukocytes, upregulate the expression of endothelial adhesion molecules, facilitate adhesion and migration of inflammatory cells into the subendothelial space, and activate the complement system. Since humans are postprandial most of the day, the continuous generation of remnants after each meal may be one of the triggers for the development of atherosclerosis. Modulation of postprandial lipemia by lifestyle changes and pharmacological interventions could result in a further decrease of cardiovascular mortality and morbidity. This paper will provide an update on current concepts concerning the relationship between postprandial lipemia, inflammation, vascular function, and therapeutic options.http://dx.doi.org/10.1155/2012/947417 |
| spellingShingle | Boudewijn Klop Spencer D. Proctor John C. Mamo Kathleen M. Botham Manuel Castro Cabezas Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic Diseases International Journal of Vascular Medicine |
| title | Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic Diseases |
| title_full | Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic Diseases |
| title_fullStr | Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic Diseases |
| title_full_unstemmed | Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic Diseases |
| title_short | Understanding Postprandial Inflammation and Its Relationship to Lifestyle Behaviour and Metabolic Diseases |
| title_sort | understanding postprandial inflammation and its relationship to lifestyle behaviour and metabolic diseases |
| url | http://dx.doi.org/10.1155/2012/947417 |
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