Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection
Enterohemorrhagic Escherichia coli serotype O157:H7 is a food- and waterborne pathogen that causes significant morbidity and mortality in both developing and industrialized nations. The present review focuses on the history, epidemiology and evolution of the pathogen; provides a mechanistic overview...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2013/138673 |
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| _version_ | 1832562272936919040 |
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| author | Nathan K Ho Aleah C Henry Kathene Johnson-Henry Philip M Sherman |
| author_facet | Nathan K Ho Aleah C Henry Kathene Johnson-Henry Philip M Sherman |
| author_sort | Nathan K Ho |
| collection | DOAJ |
| description | Enterohemorrhagic Escherichia coli serotype O157:H7 is a food- and waterborne pathogen that causes significant morbidity and mortality in both developing and industrialized nations. The present review focuses on the history, epidemiology and evolution of the pathogen; provides a mechanistic overview of major virulence factors (including Shiga toxins, locus of enterocyte effacement pathogenicity island and pO157 plasmid); discusses host immune responses to infection; considers available animal models; and provides an overview of current and potential future management considerations. |
| format | Article |
| id | doaj-art-72ec26a3e6b34eabb8b67351ea2f4062 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-72ec26a3e6b34eabb8b67351ea2f40622025-02-03T01:23:01ZengWileyCanadian Journal of Gastroenterology0835-79002013-01-0127528128510.1155/2013/138673Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 InfectionNathan K Ho0Aleah C Henry1Kathene Johnson-Henry2Philip M Sherman3Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, CanadaDepartment of Chemical Engineering, McMaster University, Hamilton, Ontario, CanadaDepartment of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, CanadaDepartment of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, CanadaEnterohemorrhagic Escherichia coli serotype O157:H7 is a food- and waterborne pathogen that causes significant morbidity and mortality in both developing and industrialized nations. The present review focuses on the history, epidemiology and evolution of the pathogen; provides a mechanistic overview of major virulence factors (including Shiga toxins, locus of enterocyte effacement pathogenicity island and pO157 plasmid); discusses host immune responses to infection; considers available animal models; and provides an overview of current and potential future management considerations.http://dx.doi.org/10.1155/2013/138673 |
| spellingShingle | Nathan K Ho Aleah C Henry Kathene Johnson-Henry Philip M Sherman Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection Canadian Journal of Gastroenterology |
| title | Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection |
| title_full | Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection |
| title_fullStr | Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection |
| title_full_unstemmed | Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection |
| title_short | Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection |
| title_sort | pathogenicity host responses and implications for management of enterohemorrhagic escherichia coli o157 h7 infection |
| url | http://dx.doi.org/10.1155/2013/138673 |
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