Explainable artificial intelligence (XAI) to find optimal in-silico biomarkers for cardiac drug toxicity evaluation

Explainable artificial intelligence (XAI) to find optimal in-silico biomarkers for cardiac drug toxicity evaluation

Abstract The Comprehensive In-vitro Proarrhythmia Assay (CiPA) initiative aims to refine the assessment of drug-induced torsades de pointes (TdP) risk, utilizing computational models to predict cardiac drug toxicity. Despite advancements in machine learning applications for this purpose, the specifi...

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Bibliographic Details
Main Authors: Muhammad Adnan Pramudito, Yunendah Nur Fuadah, Ali Ikhsanul Qauli, Aroli Marcellinus, Ki Moo Lim
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-71169-w
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