Calprotectin may be positively associated with the severity of acne vulgaris
Background and objective: Acne vulgaris (AV) is a common skin disease of sebaceous hair follicles. Many factors are associated with the occurrence and severity of acne, while the exact etiology remains incompletely understood. The current study was aimed to investigate the association between the se...
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| Format: | Article |
| Language: | English |
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College of Medicine, Al-Nahrain University
2022-06-01
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| Series: | Baghdad Journal of Biochemistry and Applied Biological Sciences |
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| Online Access: | https://bjbabs.org/index.php/bjbabs/article/view/124 |
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| author | Shireen A. Al-tameemi Zainab S. Abid WenChieh Chen Fawwaz Alshammri Hussein Abid |
| author_facet | Shireen A. Al-tameemi Zainab S. Abid WenChieh Chen Fawwaz Alshammri Hussein Abid |
| author_sort | Shireen A. Al-tameemi |
| collection | DOAJ |
| description | Background and objective: Acne vulgaris (AV) is a common skin disease of sebaceous hair follicles. Many factors are associated with the occurrence and severity of acne, while the exact etiology remains incompletely understood. The current study was aimed to investigate the association between the severity of acne and serum zinc, copper, and calprotectin.
Methods: Fifty patients with AV were recruited in the study as well as 25 healthy age and sex-matched individuals as controls. The acne severity was classified into mild (n=21), moderate (n=16), and severe acne (n=14) according to the global acne grading system (GAGS). Serum levels of zinc, acne and calprotectin were evaluated by enzyme-linked immunosorbent assay (ELISA). The gained data were analyzed using GraphPad Prism software.
Results: Insignificant difference was found in zinc and copper levels between controls and AV patients, except in severe AV, where the patients displayed significant elevation in serum copper level (p<0.05) as compared to that of mild AV. The calprotectin concentration was significantly higher (p<0.001) in all AV patients, when compared with healthy subjects, which was positively correlated with the disease severity. No gender difference was noted for all measured biomarkers.
Conclusions: Our study suggests a possible association between calprotectin and acne inflammation, which requires validation in large-scale studies. |
| format | Article |
| id | doaj-art-72eb2bc76ec344a683c66a6c702bdbd1 |
| institution | OA Journals |
| issn | 2706-9915 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | College of Medicine, Al-Nahrain University |
| record_format | Article |
| series | Baghdad Journal of Biochemistry and Applied Biological Sciences |
| spelling | doaj-art-72eb2bc76ec344a683c66a6c702bdbd12025-08-20T02:10:32ZengCollege of Medicine, Al-Nahrain UniversityBaghdad Journal of Biochemistry and Applied Biological Sciences2706-99152022-06-013214515510.47419/bjbabs.v3i02.124Calprotectin may be positively associated with the severity of acne vulgarisShireen A. Al-tameemi0Zainab S. Abid1WenChieh Chen2Fawwaz Alshammri3Hussein Abid4Department of Chemistry, College of Science, University of Diyala, Baqubah 32001, IraqMiqdadiyah Primary Healthcare Sector, Diyala Health Directorate, Iraqi Ministry of Health, Miqdadiyah 32003, IraqDepartment of Dermatology and Allergy, Technical University of Munich, Munich, GermanyDepartment of Dermatology, College of Medicine, University of Hail, Hail, Saudi ArabiaMedical Laboratory Technology Department, Technical Institute of Baquba, Middle Technical University, Baqubah 32001, IraqBackground and objective: Acne vulgaris (AV) is a common skin disease of sebaceous hair follicles. Many factors are associated with the occurrence and severity of acne, while the exact etiology remains incompletely understood. The current study was aimed to investigate the association between the severity of acne and serum zinc, copper, and calprotectin. Methods: Fifty patients with AV were recruited in the study as well as 25 healthy age and sex-matched individuals as controls. The acne severity was classified into mild (n=21), moderate (n=16), and severe acne (n=14) according to the global acne grading system (GAGS). Serum levels of zinc, acne and calprotectin were evaluated by enzyme-linked immunosorbent assay (ELISA). The gained data were analyzed using GraphPad Prism software. Results: Insignificant difference was found in zinc and copper levels between controls and AV patients, except in severe AV, where the patients displayed significant elevation in serum copper level (p<0.05) as compared to that of mild AV. The calprotectin concentration was significantly higher (p<0.001) in all AV patients, when compared with healthy subjects, which was positively correlated with the disease severity. No gender difference was noted for all measured biomarkers. Conclusions: Our study suggests a possible association between calprotectin and acne inflammation, which requires validation in large-scale studies.https://bjbabs.org/index.php/bjbabs/article/view/124acne vulgariscalgranulininflammatorycopperzinc |
| spellingShingle | Shireen A. Al-tameemi Zainab S. Abid WenChieh Chen Fawwaz Alshammri Hussein Abid Calprotectin may be positively associated with the severity of acne vulgaris Baghdad Journal of Biochemistry and Applied Biological Sciences acne vulgaris calgranulin inflammatory copper zinc |
| title | Calprotectin may be positively associated with the severity of acne vulgaris |
| title_full | Calprotectin may be positively associated with the severity of acne vulgaris |
| title_fullStr | Calprotectin may be positively associated with the severity of acne vulgaris |
| title_full_unstemmed | Calprotectin may be positively associated with the severity of acne vulgaris |
| title_short | Calprotectin may be positively associated with the severity of acne vulgaris |
| title_sort | calprotectin may be positively associated with the severity of acne vulgaris |
| topic | acne vulgaris calgranulin inflammatory copper zinc |
| url | https://bjbabs.org/index.php/bjbabs/article/view/124 |
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