PGC-1α mediates migrasome secretion accelerating macrophage–myofibroblast transition and contributing to sepsis-associated pulmonary fibrosis

PGC-1α mediates migrasome secretion accelerating macrophage–myofibroblast transition and contributing to sepsis-associated pulmonary fibrosis

Abstract Sepsis-associated pulmonary fibrosis (SAPF) is a critical pathological stage in the progression of sepsis-induced acute respiratory distress syndrome. While the aggregation and activation of lung fibroblasts are central to the initiation of pulmonary fibrosis, the macrophage–myofibroblast t...

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Main Authors: Yawen Peng, Shuya Mei, Xiaohui Qi, Ri Tang, Wenyu Yang, Jinhua Feng, Yang Zhou, Xi Huang, Guojun Qian, Shunpeng Xing, Yuan Gao, Qiaoyi Xu, Zhengyu He
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01426-z
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