Serum transgelin is a novel prognostic biomarker for COVID-19 patients
BackgroundTransgelin is a central actin-binding protein of the calponin family and involved in the process of multiple pulmonary diseases. Nevertheless, the role of transgelin in Coronavirus disease 2019 (COVID-19) patients is confusing.MethodsAll 317 COVID-19 patients were recruited from two hospit...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1423182/full |
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| author | Lei Gao Lei Gao Ying Liu Ying Liu Qi-Yuan He Qi-Yuan He Yu Wang Yu Wang Ya-Lin Jiang Jin Yang Jin Yang Lin Fu Lin Fu Hui Zhao Hui Zhao |
| author_facet | Lei Gao Lei Gao Ying Liu Ying Liu Qi-Yuan He Qi-Yuan He Yu Wang Yu Wang Ya-Lin Jiang Jin Yang Jin Yang Lin Fu Lin Fu Hui Zhao Hui Zhao |
| author_sort | Lei Gao |
| collection | DOAJ |
| description | BackgroundTransgelin is a central actin-binding protein of the calponin family and involved in the process of multiple pulmonary diseases. Nevertheless, the role of transgelin in Coronavirus disease 2019 (COVID-19) patients is confusing.MethodsAll 317 COVID-19 patients were recruited from two hospital. Peripheral blood was collected from the fasting patients at the onset and convalescent phases. Demographic data and clinical information were obtained. The expression of serum transgelin was estimated using ELISA.ResultsThe expression of serum transgelin on admission was gradually elevated in parallel with the increased severity scores of COVID-19. After treatment, serum transgelin expression was reduced during the convalescent phase. Spearman correlative analyses found that serum transgelin expression was closely correlated to lots of clinical parameters. Besides, serum transgelin was positively associated with severity scores. Follow-up research found that serum higher transgelin on admission elevated the risks of mechanical ventilation, vasoactive agent utilization, ICU admission, death, and longer hospital stays during hospitalization through a prospective cohort study. Additionally, there were similarly predictive capacities for critical patients and death between serum transgelin on admission and severity scores among COVID-19 patients.ConclusionsThe expression of serum transgelin is positively with the severity and poorly prognostic outcomes among COVID-19 patients, indicating that transgelin is implicated in the pathological process of COVID-19. Transgelin can assist in the risk stratification and revealing the pathological mechanisms of COVID-19. |
| format | Article |
| id | doaj-art-72e4584c2b274bec81f370b2d3e5cca5 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-72e4584c2b274bec81f370b2d3e5cca52025-08-20T02:06:55ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-11-011510.3389/fimmu.2024.14231821423182Serum transgelin is a novel prognostic biomarker for COVID-19 patientsLei Gao0Lei Gao1Ying Liu2Ying Liu3Qi-Yuan He4Qi-Yuan He5Yu Wang6Yu Wang7Ya-Lin Jiang8Jin Yang9Jin Yang10Lin Fu11Lin Fu12Hui Zhao13Hui Zhao14Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaInstitute of Respiratory Diseases, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaInstitute of Respiratory Diseases, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaInstitute of Respiratory Diseases, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaInstitute of Respiratory Diseases, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Bozhou People’s Hospital, Bozhou, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaInstitute of Respiratory Diseases, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaInstitute of Respiratory Diseases, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaInstitute of Respiratory Diseases, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaBackgroundTransgelin is a central actin-binding protein of the calponin family and involved in the process of multiple pulmonary diseases. Nevertheless, the role of transgelin in Coronavirus disease 2019 (COVID-19) patients is confusing.MethodsAll 317 COVID-19 patients were recruited from two hospital. Peripheral blood was collected from the fasting patients at the onset and convalescent phases. Demographic data and clinical information were obtained. The expression of serum transgelin was estimated using ELISA.ResultsThe expression of serum transgelin on admission was gradually elevated in parallel with the increased severity scores of COVID-19. After treatment, serum transgelin expression was reduced during the convalescent phase. Spearman correlative analyses found that serum transgelin expression was closely correlated to lots of clinical parameters. Besides, serum transgelin was positively associated with severity scores. Follow-up research found that serum higher transgelin on admission elevated the risks of mechanical ventilation, vasoactive agent utilization, ICU admission, death, and longer hospital stays during hospitalization through a prospective cohort study. Additionally, there were similarly predictive capacities for critical patients and death between serum transgelin on admission and severity scores among COVID-19 patients.ConclusionsThe expression of serum transgelin is positively with the severity and poorly prognostic outcomes among COVID-19 patients, indicating that transgelin is implicated in the pathological process of COVID-19. Transgelin can assist in the risk stratification and revealing the pathological mechanisms of COVID-19.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1423182/fulltransgelincohort studyCOVID-19severityprognosis |
| spellingShingle | Lei Gao Lei Gao Ying Liu Ying Liu Qi-Yuan He Qi-Yuan He Yu Wang Yu Wang Ya-Lin Jiang Jin Yang Jin Yang Lin Fu Lin Fu Hui Zhao Hui Zhao Serum transgelin is a novel prognostic biomarker for COVID-19 patients Frontiers in Immunology transgelin cohort study COVID-19 severity prognosis |
| title | Serum transgelin is a novel prognostic biomarker for COVID-19 patients |
| title_full | Serum transgelin is a novel prognostic biomarker for COVID-19 patients |
| title_fullStr | Serum transgelin is a novel prognostic biomarker for COVID-19 patients |
| title_full_unstemmed | Serum transgelin is a novel prognostic biomarker for COVID-19 patients |
| title_short | Serum transgelin is a novel prognostic biomarker for COVID-19 patients |
| title_sort | serum transgelin is a novel prognostic biomarker for covid 19 patients |
| topic | transgelin cohort study COVID-19 severity prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1423182/full |
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