DRESS Syndrome Presents as Leukoencephalopathy
DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a potentially life-threatening syndrome, which reflects a serious hypersensitivity reaction to drugs, presenting by generalized skin rash, fever, eosinophilia, atypical lymphocytosis, and internal organ involvement. Herein...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2015-10-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/1284 |
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| _version_ | 1850237208543363072 |
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| author | Seyed Hasan Tonekaboni Narjes Jafari Zahra Chavoshzadeh Bibi Shahin Shamsian Nima Rezaei |
| author_facet | Seyed Hasan Tonekaboni Narjes Jafari Zahra Chavoshzadeh Bibi Shahin Shamsian Nima Rezaei |
| author_sort | Seyed Hasan Tonekaboni |
| collection | DOAJ |
| description |
DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a potentially life-threatening syndrome, which reflects a serious hypersensitivity reaction to drugs, presenting by generalized skin rash, fever, eosinophilia, atypical lymphocytosis, and internal organ involvement. Herein a 21-month old male infant with DRESS and Encephalopathy syndrome is presented who complicated after phenobarbital usage that persisted due to phenytoin cream usage. The case received phenobarbital after a seizure disorder presented as "status epilepticus". He developed drug eruption, fever, hepatosplenomegaly, increased liver enzymes, encephalopathy and progressive loss of consciousness with extensive hyperintense white matter lesions in brain MRI. After discontinuation of phenobarbital and phenytoin, all symptoms were resolved, while brain MRI became normal after two months. To our best knowledge, this is the first reported case that developed leukoencephalopathy along with DRESS syndrome.
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| format | Article |
| id | doaj-art-72dffa8af1084d61b585dce3ea38011e |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2015-10-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-72dffa8af1084d61b585dce3ea38011e2025-08-20T02:01:47ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212015-10-01575DRESS Syndrome Presents as LeukoencephalopathySeyed Hasan Tonekaboni0Narjes JafariZahra ChavoshzadehBibi Shahin ShamsianNima RezaeiPediatric Neurology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. zahra_chavoshzadeh@yahoo.com. DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a potentially life-threatening syndrome, which reflects a serious hypersensitivity reaction to drugs, presenting by generalized skin rash, fever, eosinophilia, atypical lymphocytosis, and internal organ involvement. Herein a 21-month old male infant with DRESS and Encephalopathy syndrome is presented who complicated after phenobarbital usage that persisted due to phenytoin cream usage. The case received phenobarbital after a seizure disorder presented as "status epilepticus". He developed drug eruption, fever, hepatosplenomegaly, increased liver enzymes, encephalopathy and progressive loss of consciousness with extensive hyperintense white matter lesions in brain MRI. After discontinuation of phenobarbital and phenytoin, all symptoms were resolved, while brain MRI became normal after two months. To our best knowledge, this is the first reported case that developed leukoencephalopathy along with DRESS syndrome. https://turkjpediatr.org/article/view/1284 |
| spellingShingle | Seyed Hasan Tonekaboni Narjes Jafari Zahra Chavoshzadeh Bibi Shahin Shamsian Nima Rezaei DRESS Syndrome Presents as Leukoencephalopathy The Turkish Journal of Pediatrics |
| title | DRESS Syndrome Presents as Leukoencephalopathy |
| title_full | DRESS Syndrome Presents as Leukoencephalopathy |
| title_fullStr | DRESS Syndrome Presents as Leukoencephalopathy |
| title_full_unstemmed | DRESS Syndrome Presents as Leukoencephalopathy |
| title_short | DRESS Syndrome Presents as Leukoencephalopathy |
| title_sort | dress syndrome presents as leukoencephalopathy |
| url | https://turkjpediatr.org/article/view/1284 |
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