Fluorescein angiography patterns and subretinal hyperreflective material predict subthreshold micropulse laser response in chronic central serous chorioretinopathy
Abstract Background To investigate predictors of navigated subthreshold micropulse laser (SML) treatment in chronic central serous chorioretinopathy (cCSC). Methods In this single-center prospective consecutive case series, patients with cCSC were treated with 577 nm SML and followed up for 12 month...
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BMC
2024-11-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-024-03711-3 |
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| author | Claudio Iovino Clemente Maria Iodice Luciana Damiano Danila Pisani Francesco Testa Settimio Rossi Francesca Simonelli |
| author_facet | Claudio Iovino Clemente Maria Iodice Luciana Damiano Danila Pisani Francesco Testa Settimio Rossi Francesca Simonelli |
| author_sort | Claudio Iovino |
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| description | Abstract Background To investigate predictors of navigated subthreshold micropulse laser (SML) treatment in chronic central serous chorioretinopathy (cCSC). Methods In this single-center prospective consecutive case series, patients with cCSC were treated with 577 nm SML and followed up for 12 months. A complete ophthalmological evaluation including spectral optical coherence tomography (SD-OCT), fluorescein angiography (FA) and microperimetry (MP) was performed. FA hyperfluorescence patterns and SD-OCT features were investigated. Results Overall, 38 eyes from 38 patients affected by cCSC with a mean age of 48.20 ± 5.95 years were included. Thirty-one eyes (81.6%) demonstrated a significant subretinal fluid (SRF) reduction after treatment at 3 months. Complete SRF resolution was achieved by twenty-three patients (60.5%) at 3 months and attained by an additional patient (24 in total, 63.2%) at 6 months. Twenty-two (57.9%) of such individuals were confirmed with no SRF at the end of the follow-up. Best-corrected visual acuity improved significantly and progressively at all timepoints from baseline, in parallel with macular sensitivity (all p: <0.005). Logistic regression analysis revealed that the presence of subretinal hyperreflective material (SHRM, p: 0.044; OR: -0.225; 95% CI: -0.448 - -0.003) and focal hyperfluorescence pattern on FA (p < 0.001; OR: 0.438; 95% CI: 0.196–0.632) predicted poorer and better treatment response, respectively. Conclusions FA hyperfluorescence pattern and presence of SHRM may predict SML treatment response in cCSC patients. |
| format | Article |
| id | doaj-art-72dfdcfb34684accb5041a3bc2a26c86 |
| institution | Kabale University |
| issn | 1471-2415 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
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| series | BMC Ophthalmology |
| spelling | doaj-art-72dfdcfb34684accb5041a3bc2a26c862024-11-10T12:13:32ZengBMCBMC Ophthalmology1471-24152024-11-012411710.1186/s12886-024-03711-3Fluorescein angiography patterns and subretinal hyperreflective material predict subthreshold micropulse laser response in chronic central serous chorioretinopathyClaudio Iovino0Clemente Maria Iodice1Luciana Damiano2Danila Pisani3Francesco Testa4Settimio Rossi5Francesca Simonelli6Multidisciplinary Department of Medical, Surgical and Dental Sciences, Eye Clinic, University of Campania Luigi VanvitelliMultidisciplinary Department of Medical, Surgical and Dental Sciences, Eye Clinic, University of Campania Luigi VanvitelliMultidisciplinary Department of Medical, Surgical and Dental Sciences, Eye Clinic, University of Campania Luigi VanvitelliMultidisciplinary Department of Medical, Surgical and Dental Sciences, Eye Clinic, University of Campania Luigi VanvitelliMultidisciplinary Department of Medical, Surgical and Dental Sciences, Eye Clinic, University of Campania Luigi VanvitelliMultidisciplinary Department of Medical, Surgical and Dental Sciences, Eye Clinic, University of Campania Luigi VanvitelliMultidisciplinary Department of Medical, Surgical and Dental Sciences, Eye Clinic, University of Campania Luigi VanvitelliAbstract Background To investigate predictors of navigated subthreshold micropulse laser (SML) treatment in chronic central serous chorioretinopathy (cCSC). Methods In this single-center prospective consecutive case series, patients with cCSC were treated with 577 nm SML and followed up for 12 months. A complete ophthalmological evaluation including spectral optical coherence tomography (SD-OCT), fluorescein angiography (FA) and microperimetry (MP) was performed. FA hyperfluorescence patterns and SD-OCT features were investigated. Results Overall, 38 eyes from 38 patients affected by cCSC with a mean age of 48.20 ± 5.95 years were included. Thirty-one eyes (81.6%) demonstrated a significant subretinal fluid (SRF) reduction after treatment at 3 months. Complete SRF resolution was achieved by twenty-three patients (60.5%) at 3 months and attained by an additional patient (24 in total, 63.2%) at 6 months. Twenty-two (57.9%) of such individuals were confirmed with no SRF at the end of the follow-up. Best-corrected visual acuity improved significantly and progressively at all timepoints from baseline, in parallel with macular sensitivity (all p: <0.005). Logistic regression analysis revealed that the presence of subretinal hyperreflective material (SHRM, p: 0.044; OR: -0.225; 95% CI: -0.448 - -0.003) and focal hyperfluorescence pattern on FA (p < 0.001; OR: 0.438; 95% CI: 0.196–0.632) predicted poorer and better treatment response, respectively. Conclusions FA hyperfluorescence pattern and presence of SHRM may predict SML treatment response in cCSC patients.https://doi.org/10.1186/s12886-024-03711-3Chronic central serous chorioretinopathyFluorescein angiographyOptical coherence tomographyPredictorsSubthreshold micropulse laser |
| spellingShingle | Claudio Iovino Clemente Maria Iodice Luciana Damiano Danila Pisani Francesco Testa Settimio Rossi Francesca Simonelli Fluorescein angiography patterns and subretinal hyperreflective material predict subthreshold micropulse laser response in chronic central serous chorioretinopathy BMC Ophthalmology Chronic central serous chorioretinopathy Fluorescein angiography Optical coherence tomography Predictors Subthreshold micropulse laser |
| title | Fluorescein angiography patterns and subretinal hyperreflective material predict subthreshold micropulse laser response in chronic central serous chorioretinopathy |
| title_full | Fluorescein angiography patterns and subretinal hyperreflective material predict subthreshold micropulse laser response in chronic central serous chorioretinopathy |
| title_fullStr | Fluorescein angiography patterns and subretinal hyperreflective material predict subthreshold micropulse laser response in chronic central serous chorioretinopathy |
| title_full_unstemmed | Fluorescein angiography patterns and subretinal hyperreflective material predict subthreshold micropulse laser response in chronic central serous chorioretinopathy |
| title_short | Fluorescein angiography patterns and subretinal hyperreflective material predict subthreshold micropulse laser response in chronic central serous chorioretinopathy |
| title_sort | fluorescein angiography patterns and subretinal hyperreflective material predict subthreshold micropulse laser response in chronic central serous chorioretinopathy |
| topic | Chronic central serous chorioretinopathy Fluorescein angiography Optical coherence tomography Predictors Subthreshold micropulse laser |
| url | https://doi.org/10.1186/s12886-024-03711-3 |
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