Olanzapine-induced hypertriglyceridemia in cancer care: A silent metabolic risk

Olanzapine (Zyprexa), an atypical antipsychotic, is used off-label for managing nausea in advanced cancer patients but is linked to severe metabolic side effects, including hypertriglyceridemia. This case involves a metastatic gastric carcinoma patient with no known metabolic disorder who developed...

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Main Authors: Bilal Kazi, Imaan Rumani, Marzooka Nazim Chishti Kazi, Prashant Manohar Gaikwad
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Current Problems in Cancer: Case Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2666621924000668
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author Bilal Kazi
Imaan Rumani
Marzooka Nazim Chishti Kazi
Prashant Manohar Gaikwad
author_facet Bilal Kazi
Imaan Rumani
Marzooka Nazim Chishti Kazi
Prashant Manohar Gaikwad
author_sort Bilal Kazi
collection DOAJ
description Olanzapine (Zyprexa), an atypical antipsychotic, is used off-label for managing nausea in advanced cancer patients but is linked to severe metabolic side effects, including hypertriglyceridemia. This case involves a metastatic gastric carcinoma patient with no known metabolic disorder who developed critically elevated triglycerides (2898 mg/dL) after starting olanzapine for nausea. Her lipid levels significantly improved with medical management, allowing her to proceed for apheresis for the planned CAR-T treatment. This case underscores the need for vigilant metabolic monitoring in patients on Olanzapine (Zyprexa), even those without known risk factors, to prevent serious complications.
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id doaj-art-72d98a96e6fd4094b1dae4d86925166a
institution DOAJ
issn 2666-6219
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publishDate 2025-03-01
publisher Elsevier
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series Current Problems in Cancer: Case Reports
spelling doaj-art-72d98a96e6fd4094b1dae4d86925166a2025-08-20T02:51:35ZengElsevierCurrent Problems in Cancer: Case Reports2666-62192025-03-011710034510.1016/j.cpccr.2024.100345Olanzapine-induced hypertriglyceridemia in cancer care: A silent metabolic riskBilal Kazi0Imaan Rumani1Marzooka Nazim Chishti Kazi2Prashant Manohar Gaikwad3SUNACT Cancer Institute. Department of Hematology, Bone Marrow Transplantation and Cellular therapy, Tietan Medicity Hospital, Kasarvadavali, Thane, 400615, Maharashtra, India; Corresponding author.SUNACT Cancer Institute. Department of Oncosurgery, Tietan Medicity Hospital, Kasarvadavali, Thane, 400615, Maharashtra, IndiaDepartment of Pharmaceutics. Y.B Chavhan College of Pharmacy. Aurangabad, IndiaDepartment of endocrinology, MGM Medical College and Hospital, Navi Mumbai, IndiaOlanzapine (Zyprexa), an atypical antipsychotic, is used off-label for managing nausea in advanced cancer patients but is linked to severe metabolic side effects, including hypertriglyceridemia. This case involves a metastatic gastric carcinoma patient with no known metabolic disorder who developed critically elevated triglycerides (2898 mg/dL) after starting olanzapine for nausea. Her lipid levels significantly improved with medical management, allowing her to proceed for apheresis for the planned CAR-T treatment. This case underscores the need for vigilant metabolic monitoring in patients on Olanzapine (Zyprexa), even those without known risk factors, to prevent serious complications.http://www.sciencedirect.com/science/article/pii/S2666621924000668Olanzapine (Zyprexa)NauseaHypertriglyceridemiaDyslipidemia
spellingShingle Bilal Kazi
Imaan Rumani
Marzooka Nazim Chishti Kazi
Prashant Manohar Gaikwad
Olanzapine-induced hypertriglyceridemia in cancer care: A silent metabolic risk
Current Problems in Cancer: Case Reports
Olanzapine (Zyprexa)
Nausea
Hypertriglyceridemia
Dyslipidemia
title Olanzapine-induced hypertriglyceridemia in cancer care: A silent metabolic risk
title_full Olanzapine-induced hypertriglyceridemia in cancer care: A silent metabolic risk
title_fullStr Olanzapine-induced hypertriglyceridemia in cancer care: A silent metabolic risk
title_full_unstemmed Olanzapine-induced hypertriglyceridemia in cancer care: A silent metabolic risk
title_short Olanzapine-induced hypertriglyceridemia in cancer care: A silent metabolic risk
title_sort olanzapine induced hypertriglyceridemia in cancer care a silent metabolic risk
topic Olanzapine (Zyprexa)
Nausea
Hypertriglyceridemia
Dyslipidemia
url http://www.sciencedirect.com/science/article/pii/S2666621924000668
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AT marzookanazimchishtikazi olanzapineinducedhypertriglyceridemiaincancercareasilentmetabolicrisk
AT prashantmanohargaikwad olanzapineinducedhypertriglyceridemiaincancercareasilentmetabolicrisk