Examination of age- and sex-related changes in protein expression within the hippocampus and prefrontal cortex during withdrawal from a subchronic history of binge-drinking in C57BL/6J mice

Examination of age- and sex-related changes in protein expression within the hippocampus and prefrontal cortex during withdrawal from a subchronic history of binge-drinking in C57BL/6J mice

IntroductionEarly-onset binge-drinking and biological sex are critical risk factors for the development of cognitive decline and neurodegeneration associated with Alzheimer’s disease and related dementias (ADRDs). Recently, we demonstrated that a prior history of binge-drinking during adolescence in...

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Bibliographic Details
Main Authors: C. Leonardo Jimenez Chavez, Lauren E. Madory, Chris J. E. Denning, Edward C. Lee, Dylan T. Nguyen, Gavin P. Scheldrup, Karen K. Szumlinski
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
adolescence
group 1 metabotropic glutamate receptors
tau
prefrontal cortex
hippocampus
sex differences
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2025.1619889/full
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