Spectral cytometry of rheumatoid arthritis patients implicates myeloid dendritic cells and granular HLA-DR+CD15+CD16+ cells in pro-inflammatory antigen presentation

Spectral cytometry of rheumatoid arthritis patients implicates myeloid dendritic cells and granular HLA-DR+CD15+CD16+ cells in pro-inflammatory antigen presentation

IntroductionRheumatoid arthritis (RA) is a systemic autoimmune disease that leads to inflammation of synovial joints and other organs. Many RA patients “share” a common peptide sequence within the HLA-DR (MHC II) molecule expressed on antigen-presenting cells (APC), suggesting that HLA-DR+ cells are...

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Bibliographic Details
Main Authors: Christian Geier, Haani Qudsi, Estelle Khairallah, Jihad Ben Gabr, Robert Winchester, Andras Perl
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
CD1c+ dendritic cells
intermediate monocytes
myeloid cells
low-density granulocytes
antigen-presenting cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1596609/full
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